{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:34:35Z","timestamp":1786977275294,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,2,5]],"date-time":"2020-02-05T00:00:00Z","timestamp":1580860800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the major project of Fujian Provincial Department of Science and Technology","award":["2014YZ0003"],"award-info":[{"award-number":["2014YZ0003"]}]},{"name":"the key clinical specialty discipline construction program of Fujian, P.R.C."}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The neuroglobin (Ngb) is well recognized as a potential biomarker for the hypoxic\u2010ischemic brain injury. However, connection between Ngb and delayed cerebral ischemia (DCI) following aneurysmal subarachnoid hemorrhage (aSAH) is still unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the relationship between early stage Ngb level of aSAH patient and the occurrence of DCI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We evaluated 126 aSAH patients who were enrolled into a prospective observational cohort study. Serum Ngb level on days 1, 2, 3, 5, and 7 after aSAH were determined using a commercial enzyme\u2010linked immunosorbent assay kit. The relationship between Ngb level and DCI was analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Forty\u2010six (36.5%) aSAH patients experienced DCI. Patients with DCI had significantly higher Ngb levels than those without (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.001). Multivariate model analysis revealed that day 3 Ngb level remained a significant factor after adjusting for World Federation of Neurosurgical Societies (WFNS) grade, modified Fisher grade, clipping and Ngb levels on days 1, 2, 5, and 7. Sensitivity, specificity, and\n                      <jats:italic>Youden<\/jats:italic>\n                      index of day 3 Ngb level for identifying DCI were derived as 73.9%, 72.5%, and 0.46, respectively, based on the best threshold of 8.4\u00a0ng\/ml. Regardless in good\u2010grade group or in poor\u2010grade group, patients having day 3 Ngb level\u00a0&gt;\u00a08.4\u00a0ng\/ml has a significantly worse DCI survival rate than those having day 3 Ngb level &lt;=8.4\u00a0ng\/ml (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.026 and .009, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Serum Ngb level was significantly elevated in DCI patients. Early stage aSAH Ngb level has the potential of being used as a novel DCI occurrence predictor, especially when Ngb level was combined with WFNS grade.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.1547","type":"journal-article","created":{"date-parts":[[2020,2,5]],"date-time":"2020-02-05T21:42:23Z","timestamp":1580938943000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Early stage neuroglobin level as a predictor of delayed cerebral ischemia in patients with aneurysmal subarachnoid hemorrhage"],"prefix":"10.1002","volume":"10","author":[{"given":"Chenyu","family":"Ding","sequence":"first","affiliation":[{"name":"Department of Neurosurgery The First Affiliated Hospital of Fujian Medical University Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dezhi","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The First Affiliated 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