{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T10:34:04Z","timestamp":1790505244750,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,1,27]],"date-time":"2020-01-27T00:00:00Z","timestamp":1580083200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital","doi-asserted-by":"publisher","award":["107\u2010S3747"],"award-info":[{"award-number":["107\u2010S3747"]}],"id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital","doi-asserted-by":"publisher","award":["UN108\u2010023"],"award-info":[{"award-number":["UN108\u2010023"]}],"id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Frontal variant of Alzheimer's disease (fvAD) is a rare nonamnestic syndrome of Alzheimer's disease (AD). Differentiating it from behavior variant of frontotemporal dementia (bvFTD), which has implications for treatment responses and prognosis, remains a clinical challenge.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Molecular neuroimaging and biofluid markers were performed for the index patient for accurate premortem diagnosis of fvAD. The clinical, neuroimaging, and biofluid characteristics of the patient were compared to those reported in previous studies of fvAD from 1999 to 2019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A 66\u2010year\u2010old man presented with progressive executive dysfunction, personality and behavioral changes, and memory decline since age 59. He had no family history of neurodegenerative disorders. A stimulus\u2010sensitive myoclonus was noted over his left upper extremity. Neuropsychological assessment revealed moderate dementia with a Mini\u2010Mental State Exam score of 10\/30 and compromised executive and memory performance. Brain imaging showed asymmetrical atrophy and hypometabolism over the right frontal and temporal areas, mimicking bvFTD. However, we observed increased tau depositions based on <jats:sup>18<\/jats:sup>F\u2010labeled T807 Tau PET in these areas and diffusely increased amyloid deposition based on <jats:sup>11<\/jats:sup>C\u2010labeled Pittsburgh compound B positron emission tomography (PET). Plasma biomarker measures indicated an AD profile with increased A\u03b21\u201042 (18.66\u00a0pg\/ml; cutoff: 16.42\u00a0pg\/ml), A\u03b21\u201042\/A\u03b21\u201040 ratio (0.45; cutoff: 0.30), total tau (29.78\u00a0pg\/ml; cutoff: 23.89\u00a0pg\/ml), and phosphorylated tau (4.11\u00a0pg\/ml; cutoff: 3.08\u00a0pg\/ml). These results supported a diagnosis of fvAD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results with asymmetrical presentations extend current knowledge about this rare AD variant. Application of biofluid and molecular imaging markers could assist in early, accurate diagnosis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.1548","type":"journal-article","created":{"date-parts":[[2020,1,28]],"date-time":"2020-01-28T01:44:34Z","timestamp":1580175874000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Frontal variant of Alzheimer's disease with asymmetric presentation mimicking frontotemporal dementia: Case report and literature review"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9707-1929","authenticated-orcid":false,"given":"Cheng\u2010Hsuan","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neurology National Taiwan University Hospital Taipei Taiwan"},{"name":"Department of Neurology National Taiwan University Hospital Hsinchu Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung\u2010Pin","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Neurology National Taiwan University Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ta\u2010Fu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology National Taiwan University Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Jang","family":"Chiu","sequence":"additional","affiliation":[{"name":"Department of Neurology National Taiwan University Hospital Taipei Taiwan"},{"name":"Graduate Institute of Brain and Mind Sciences College of Medicine National Taiwan University Taipei Taiwan"},{"name":"Graduate Institute of Biomedical Engineering and Bioinformatics National Taiwan University Taipei Taiwan"},{"name":"Graduate institute of Psychology National Taiwan University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruoh\u2010Fang","family":"Yen","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine National Taiwan University Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8566-7573","authenticated-orcid":false,"given":"Chin\u2010Hsien","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Neurology National Taiwan University Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,1,27]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm213"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1076\/clin.16.3.331.13846"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-131241"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2015.03.002"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-122059"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.2174\/156720512804142967"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/cn400129p"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1980-57642013DN70100011"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2009.199505"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70090-0"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-160690"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-007-0523-1"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20873"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100009768"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.2174\/1567205010666131212120443"},{"key":"e_1_2_5_17_1","first-page":"542","article-title":"Frontal variant of Alzheimer's disease. 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