{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:31:31Z","timestamp":1786977091335,"version":"build-2736575974"},"reference-count":74,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,2,7]],"date-time":"2020-02-07T00:00:00Z","timestamp":1581033600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Explore trauma, stress, and other predictive factors for treatment outcome in conversion disorder\/functional neurological disorder (CD\/FND).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospective observational design. Clinical cohort study among consecutive outpatients with DSM\u2010IV CD\/FND in a specialized mental health institution for somatic symptom disorders and related disorders (SSRD), presented between 1 February 2010 and 31 December 2017. Patient files were assessed for early childhood trauma, childhood sexual abuse, current stress, and other predictive factors. Patient\u2010related routine outcome monitoring (PROM) data were evaluated for treatment outcome at physical (Patient Health Questionnaire [PHQ15], Physical Symptoms Questionnaire [PSQ]) level as primary outcome, and depression (Patient Health Questionnaire [PHQ9]), anxiety (General Anxiety Disorder [GAD7]), general functioning (Short Form 36 Health Survey [SF36]), and pain (Brief Pain Inventory [BPI]) as secondary outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 64 outpatients were included in the study. 70.3% of the sample reported childhood trauma and 64.1% a recent life event. Mean scores of patients proceeding to treatment improved. Sexual abuse in childhood (\n                      <jats:italic>F<\/jats:italic>\n                      (1, 28)\u00a0=\u00a030.068,\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u00a0=\u00a00.608\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\u00a0.001) was significantly associated with worse physical (PHQ15, PSQ) treatment outcome. 42.2% reported comorbid depression, and this was significantly associated with worse concomitant depressive (PHQ9) (\n                      <jats:italic>F<\/jats:italic>\n                      [1, 39]\u00a0=\u00a011.526,\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u00a0=\u00a00.478,\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      =\u00a0.002) and anxiety (GAD7) (\n                      <jats:italic>F<\/jats:italic>\n                      [1,34]\u00a0=\u00a07.950,\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u00a0=\u00a00.435,\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      =\u00a0.008) outcome.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Childhood sexual abuse is significantly associated with poor treatment outcome in CD\/FND. Randomized clinical trials evaluating treatment models addressing childhood sexual abuse in CD are needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.1558","type":"journal-article","created":{"date-parts":[[2020,2,7]],"date-time":"2020-02-07T11:39:17Z","timestamp":1581075557000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Childhood sexual abuse predicts treatment outcome in conversion disorder\/functional neurological disorder. An observational longitudinal study"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6925-8956","authenticated-orcid":false,"given":"Christina M.","family":"Van der Feltz\u2010Cornelis","sequence":"first","affiliation":[{"name":"Clinical Centre of Excellence for Body, Mind and Health GGz Breburg Tilburg The Netherlands"},{"name":"Tranzo Department Tilburg University Tilburg The Netherlands"},{"name":"Department of Health Sciences HYMS University of York York UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah F.","family":"Allen","sequence":"additional","affiliation":[{"name":"Department of Health Sciences HYMS University of York York UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0723-526X","authenticated-orcid":false,"given":"Jonna F.","family":"Van Eck van der Sluijs","sequence":"additional","affiliation":[{"name":"Clinical Centre of Excellence for Body, Mind and Health GGz Breburg Tilburg The Netherlands"},{"name":"Tranzo Department Tilburg University Tilburg The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,2,7]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.5152\/npa.2017.19184"},{"issue":"3","key":"e_1_2_11_3_1","first-page":"205","article-title":"Progress in understanding conversion disorder","volume":"1","author":"Allin M.","year":"2005","journal-title":"Neuropsychiatric Disease and Treatment"},{"key":"e_1_2_11_4_1","volume-title":"The Adverse Childhood Experiences (ACE) Study: Bridging the gap between childhood trauma and negative consequences later in life","author":"Anda R. F.","year":"1998"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2017.08.023"},{"key":"e_1_2_11_6_1","volume-title":"Diagnostic and statistical manual of mental disorders, fourth edition (DSM\u2010IV)","author":"Association AP","year":"2001"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/YCO.0b013e3282f94242"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2018.09.039"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.312.7040.1215"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2004.04.011"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v68n1110"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2011-301860"},{"key":"e_1_2_11_14_1","volume-title":"Prevalence of Individual Adverse Childhood Experiences","author":"Centers for Disease Control and Prevention","year":"2016"},{"issue":"2","key":"e_1_2_11_15_1","first-page":"129","article-title":"Pain assessment: Global use of the brief pain inventory","volume":"23","author":"Cleeland C. S.","year":"2004","journal-title":"Annals Academy of Medicine"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2017.06.003"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000446660"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-014-7495-4"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4603(01)00204-0"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.160.8.1453"},{"issue":"3","key":"e_1_2_11_21_1","first-page":"861","article-title":"Conversion disorder","volume":"24","author":"Feinstein A.","year":"2018","journal-title":"Continuum (Minneapolis, Minn)"},{"key":"e_1_2_11_22_1","first-page":"169","article-title":"Psychiatric outcome in patients with a psychogenic movement disorder: A prospective study","volume":"14","author":"Feinstein A. R.","year":"2001","journal-title":"Neuropsychiatry, Neuropsychology, and Behavioral Neurology"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2012-304062"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2013-305321"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0033-3182(98)71361-1"},{"key":"e_1_2_11_26_1","volume-title":"STrengthening the Reporting of OBservational studies in Epidemiology (STROBE)","author":"Group S","year":"2007"},{"key":"e_1_2_11_27_1","doi-asserted-by":"crossref","DOI":"10.1093\/oso\/9780192632548.001.0001","volume-title":"Contemporary approaches to the study of hysteria: Clinical and theoretical perspectives","author":"Halligan P.","year":"2001"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3999(67)90010-4"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-8343(98)00057-7"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psym.2018.08.004"},{"key":"e_1_2_11_31_1","first-page":"168","article-title":"Foreign accent syndrome as a psychogenic disorder: A review","volume":"10","author":"Keulen S.","year":"2016","journal-title":"Frontiers in Human Neuroscience"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2018-318297"},{"key":"e_1_2_11_33_1","first-page":"895","article-title":"Temperamental traits associated with conversion disorder","volume":"43","author":"Krishknakumar P.","year":"2006","journal-title":"Indian Pediatrics"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.genhosppsych.2010.03.006"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2008.06.026"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1159\/000288360"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2018.10.114"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(18)30051-8"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.169.3.282"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2005.12.005"},{"issue":"2","key":"e_1_2_11_41_1","first-page":"CD006370","article-title":"Psychological and behavioural treatments for adults with non\u2010epileptic attack disorder","volume":"11","author":"Martlew J. P. J.","year":"2014","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2015.06.017"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2014-310181"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1159\/000049348"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1076\/iceh.51.1.29.14067"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2013.05.006"},{"key":"e_1_2_11_47_1","volume-title":"Psychometric theory","author":"Nunnaly J.","year":"1994"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neucli.2014.04.004"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2016-314998"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12773"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2018-318298"},{"issue":"2","key":"e_1_2_11_52_1","first-page":"150","article-title":"Conversion disorder in an internal medicine department: A series of 37 cases","volume":"42","author":"R\u00e9gny P.","year":"2016","journal-title":"Encephale French"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.nmd.0000172472.60197.4d"},{"key":"e_1_2_11_54_1","first-page":"CD005331","article-title":"Psychosocial interventions for conversion disorder","volume":"4","author":"Ruddy R.","year":"2005","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1159\/000071900"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2008.01611.x"},{"issue":"20","key":"e_1_2_11_57_1","first-page":"22","article-title":"The Mini\u2010International Neuropsychiatric Interview (M.I.N.I.): The development and validation of a structured diagnostic psychiatric interview for DSM\u2010IV and ICD\u201010","volume":"59","author":"Sheehan D. V.","year":"1998","journal-title":"The Journal of Clinical Psychiatry"},{"key":"e_1_2_11_58_1","volume-title":"Instruction manual for the Structured Clinical Interview for the DSM\u2010III (SCID)","author":"Spitzer R. L.","year":"1983"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001063"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq068"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-801772-2.00024-2"},{"issue":"4","key":"e_1_2_11_62_1","first-page":"269","article-title":"Conversion disorder\u2010review. [Icelandic]","volume":"95","author":"Sveinson O. A.","year":"2009","journal-title":"Laeknabladid"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2003.12.005"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-5215.2012.00676.x"},{"issue":"8","key":"e_1_2_11_65_1","first-page":"577","article-title":"The conversion disorder in the DSM\u20105: What's in a name?","volume":"57","author":"Van der Feltz\u2010Cornelis C. M.","year":"2015","journal-title":"Dutch. Tijdschrpsychiatr."},{"issue":"6","key":"e_1_2_11_66_1","first-page":"375","article-title":"Does routine outcome monitoring have a promising future? An investigation into the use of shared decision\u2010making combined with ROM for patients with a combination of physical and psychiatric symptoms","volume":"56","author":"Van der Feltz\u2010Cornelis C. M.","year":"2014","journal-title":"TijdschrPsychiatr"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2011.11.007"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2018.12.096"},{"issue":"18","key":"e_1_2_11_69_1","first-page":"A1244","article-title":"The Dutch multidisciplinary guideline entitled 'Medically unexplained physical symptoms and somatoform disorder","volume":"155","author":"Van der Feltz\u2010Cornelis C. M.","year":"2011","journal-title":"Nederlands Tijdschrift Voor Geneeskunde"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psym.2017.02.008"},{"key":"e_1_2_11_71_1","volume-title":"Lichamelijke Klachten Vragenlijst","author":"Van Hemert A. M.","year":"2003"},{"issue":"8","key":"e_1_2_11_72_1","first-page":"569","article-title":"Conversiestoornis: Van DSM\u2010IV naar DSM\u20105 of van psychiatrische naar neurologische diagnose","volume":"57","author":"Vermeulen M.","year":"2015","journal-title":"Tijdschrift Voor Psychiatrie"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199206000-00002"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3999(94)90056-6"},{"issue":"3","key":"e_1_2_11_75_1","first-page":"123","article-title":"Analysis of pain and interference patterns with brief pain inventory in patients with bone metastases: A confirmatory study","volume":"2","author":"Zeng L.","year":"2011","journal-title":"World Journal of Oncology"}],"container-title":["Brain and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbrb3.1558","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.1558","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/brb3.1558","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.1558","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T02:55:28Z","timestamp":1722394528000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/brb3.1558"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,7]]},"references-count":74,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["10.1002\/brb3.1558"],"URL":"https:\/\/doi.org\/10.1002\/brb3.1558","archive":["Portico"],"relation":{},"ISSN":["2162-3279","2162-3279"],"issn-type":[{"value":"2162-3279","type":"print"},{"value":"2162-3279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,7]]},"assertion":[{"value":"2019-10-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01558"}}