{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T18:15:34Z","timestamp":1777140934558,"version":"3.51.4"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,2,25]],"date-time":"2020-02-25T00:00:00Z","timestamp":1582588800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004305","name":"Shahroud University of Medical Sciences","doi-asserted-by":"publisher","award":["9751"],"award-info":[{"award-number":["9751"]}],"id":[{"id":"10.13039\/501100004305","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Cardiovascular disorders are common in patients with panic disorder (PD), usually mediated by platelets. The present study was conducted to evaluate oxidative stress conditions and complete analysis of blood cells in patients with PD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting and Sample Population<\/jats:title>\n                    <jats:p>Sixty healthy individuals and 60 patients were included in the study. Whole blood and serum samples were obtained from patients and controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials &amp; Method<\/jats:title>\n                    <jats:p>Hematological studies, including blood cells count, hemoglobin, and hematocrit, were carried out on whole blood samples. In addition, oxidative stress indices including total antioxidant capacity, free oxygen species, and malondialdehyde concentration were measured in serum samples.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Results showed that patients with PD had a significant increase in mean platelet volume index (MPV), platelet distribution width (PDW), red blood cell distribution width (RDW), and mean corpuscular hemoglobin concentration (MCHC) compared with healthy subjects (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.05). Also, oxidative stress indices were significantly elevated in patients with PD compared with control group (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Elevated MPV is a hematologic indicator for patients with PD. This disorder may be caused by impaired serotonin metabolism, resulting in increased oxidative stress, as well as in platelet serotonin transporters. Regarding elevated oxidative stress, the risk of cardiovascular complications is high in patients with PD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.1569","type":"journal-article","created":{"date-parts":[[2020,2,25]],"date-time":"2020-02-25T12:58:07Z","timestamp":1582635487000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Changes in mean platelet volume and hematologic indices in patients with panic disorder due to oxidative stress"],"prefix":"10.1002","volume":"10","author":[{"given":"Maryam","family":"Naghipour Hamzekolaei","sequence":"first","affiliation":[{"name":"Veterinary School Orumiyeh University Orumiyeh Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8341-6049","authenticated-orcid":false,"given":"Moslem","family":"Jafarisani","sequence":"additional","affiliation":[{"name":"Clinical Biochemistry School of Medicine Shahroud University of Medical Sciences Shahroud Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asghar","family":"Farajzadeh","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Sciences Ardabil Branch Islamic Azad University Ardabil Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyed Shahrokh","family":"Aghayan","sequence":"additional","affiliation":[{"name":"School of Medicine Shahroud University of Medical Sciences Shahroud Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amir","family":"Atashi","sequence":"additional","affiliation":[{"name":"Department of Hematology School of Allied Medicine Shahroud University of Medical Sciences Shahroud Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Yarmohammadi","sequence":"additional","affiliation":[{"name":"School of Medicine Shahroud University of Medical Sciences Shahroud Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iman","family":"Sadeghi","sequence":"additional","affiliation":[{"name":"Genetic, Ceinge Biotechnologia Avanzate Napl Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mersedeh","family":"Tashakori","sequence":"additional","affiliation":[{"name":"Department of Biology, Science and Research Branch Islamic Azad University Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,2,25]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"1","article-title":"Increased oxidative stress, altered trace elements, and macro\u2010minerals are associated with female obesity","author":"Amin M. 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