{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:01:43Z","timestamp":1772118103346,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,3,17]],"date-time":"2020-03-17T00:00:00Z","timestamp":1584403200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Lotterywest","award":["107\/20090827"],"award-info":[{"award-number":["107\/20090827"]}]},{"name":"NHMRC Principal Research Fellowship","award":["1117148"],"award-info":[{"award-number":["1117148"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Serum neurofilament light protein (NfL) is a promising marker of disease onset and progression in Huntington's disease (HD). This study investigated associations between lifestyle factors and NfL levels in HD mutation carriers compared to healthy age\u2010 and sex\u2010matched controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Participants included 29 HD mutation carriers and 15 healthy controls. Associations between serum NfL concentrations and lifestyle factors, including cardiorespiratory fitness, social network size and diversity, physical activity, cognitive reserve, smoking status, and alcohol consumption, were examined using a stepwise multivariable linear regression model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Higher NfL levels were associated with lower cognitive reserve, social network size and diversity and cardiorespiratory fitness in HD mutation carriers. Group\u00a0\u00d7\u00a0lifestyle factor effects were observed between lower serum NfL levels and a greater social network diversity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings highlight a relationship between lifestyle factors and NfL levels in HD mutations carriers; however, longitudinal studies are required to confirm if these observed relationships persist over time.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.1578","type":"journal-article","created":{"date-parts":[[2020,3,17]],"date-time":"2020-03-17T05:46:45Z","timestamp":1584424005000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["The relationship between lifestyle and serum neurofilament light protein in Huntington\u2019s disease"],"prefix":"10.1002","volume":"10","author":[{"given":"Travis","family":"Cruickshank","sequence":"first","affiliation":[{"name":"School of Medical and Health Sciences Edith Cowan University Perth WA Australia"},{"name":"Perron Institute for Neurological and Translational Science Perth WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6096-3760","authenticated-orcid":false,"given":"Danielle","family":"Bartlett","sequence":"additional","affiliation":[{"name":"School of Medical and Health Sciences Edith Cowan University Perth WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Govus","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, Nutrition and Sport School of Allied Health La Trobe University Melbourne VIC Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Hannan","sequence":"additional","affiliation":[{"name":"The Florey Institute of Neuroscience and Mental Health University of Melbourne Parkville VIC Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3929-9778","authenticated-orcid":false,"given":"Wei\u2010Peng","family":"Teo","sequence":"additional","affiliation":[{"name":"Institute for Physical Activity and Nutrition (IPAN) Deakin University Geelong VIC Australia"},{"name":"Physical Education and Sports Science (PESS) Academic Group National Institute of Education Nanyang Technological University Nanyang Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Mason","sequence":"additional","affiliation":[{"name":"John Van Geest Centre for Brain Repair University of Cambridge Cambridge 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