{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:01:59Z","timestamp":1772118119982,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,3,3]],"date-time":"2020-03-03T00:00:00Z","timestamp":1583193600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81171147"],"award-info":[{"award-number":["81171147"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Peripheral neurotization, recently as a promising approach, has taken effect in recovering motor function after damage to a peripheral nerve root. Neural anastomosis comprised of nerve conduit and neurorrhaphy participates in the nerve reconstruction. Current literature lacks evidence supporting an individualized coaptation for rescue of locomotor loss in rat subjects with paraplegia secondary to peripheral nerve injury (PNI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This meta\u2010analysis intends to qualify the specificity of gap\u2010specific coaptation in treating a paralyzed limb following PNI. We used a highly sensitive search strategy to identify all published studies in multiple databases up to 1 May 2019. All identified trials were systematically evaluated using specific inclusion and exclusion criteria. Cochrane methodology was also applied to the results of this study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twelve studies, including 349 rat subjects, met eligibility criteria. For a medium nerve defect (0.5\u20133.0\u00a0cm), nerve conduit was more likely than neurorrhaphy to precipitate axon regeneration and improve motor outcome of the hemiplegic limb (OR\u00a0=\u00a03.61, 95% CI\u00a0=\u00a01.80, 7.26,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.0003) at 3\u2010month follow\u2010up, whereas neurorrhaphy might take its place in promoting limb motor function in a small nerve gap (&lt;0.5\u00a0cm) (OR\u00a0=\u00a00.48, 95% CI\u00a0=\u00a00.22, 1.07,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.007). For a small nerve defect, nerve conduit still demonstrated visible effectiveness in recovery of limb motion albeit poorer than neurorrhaphy (OR\u00a0=\u00a01.50, 95% CI\u00a0=\u00a00.92, 2.47,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Selective neurotization facilitates motor regeneration after nerve transection, and advisable choice of neural coaptation can maximize functional outcome on an individual basis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.1582","type":"journal-article","created":{"date-parts":[[2020,3,4]],"date-time":"2020-03-04T00:31:31Z","timestamp":1583281891000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Efficacy evaluation of personalized coaptation in neurotization for motor deficit after peripheral nerve injury: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1864-8935","authenticated-orcid":false,"given":"TengDa","family":"Qian","sequence":"first","affiliation":[{"name":"Department of Neurosurgery First Affiliated Hospital of Nanjing Medical University Nanjing China"},{"name":"Department of Neurosurgery Jintan Hospital affiliated to Jiangsu University Jintan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery First Affiliated Hospital of Nanjing Medical University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TuoYe","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery First Affiliated Hospital of Nanjing Medical University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery First Affiliated Hospital of Nanjing Medical University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery First Affiliated Hospital of Nanjing Medical University Nanjing China"},{"name":"Department of Neurosurgery Changzhou first people's Hospital Suzhou University Changzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ZeWu","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery First Affiliated Hospital of Nanjing Medical University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ChengMing","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery First Affiliated Hospital of Nanjing Medical University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LiXin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery First Affiliated Hospital of Nanjing Medical University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,3,3]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"1","article-title":"Novel method for restoration of anorectal function following spinal cord injury via nerve transfer in rats","author":"Bao B.","year":"2018","journal-title":"Journal of Spinal Cord 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