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This study aimed to evaluate the efficacy and safety of an anthroposophic multimodal treatment for chronic pain in PPS outpatients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A twelve\u2010week, four\u2010arm, randomized, double\u2010blind, placebo\u2010controlled, phase 2 prospective clinical trial was designed to compare four groups (<jats:italic>n<\/jats:italic>\u00a0=\u00a048): groups A and B received daily active experimental transdermal gel (ETG) or placebo gel (PTG), respectively; groups C and D received weekly external therapies, art therapies, and neurofunctional reorganization, plus either daily ETG or PTG, respectively. The pain symptoms were evaluated through a visual analogue scale (VAS), the McGill questionnaire, and thermography. Quality of life and resilience were evaluated by the WHOQOL\u2010BREF and Antonovsky sense of coherence questionnaires applied at baseline and after the interventions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No related adverse events occurred, and 10% of the patients reports dysphagia improvement. In the groups C and D, pain reduction was statistically significant in both the placebo group (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.02, <jats:italic>d<\/jats:italic>\u00a0=\u00a01.315) and in the ETG (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.005, <jats:italic>d<\/jats:italic>\u00a0=\u00a02.035). However, following the week\u2010to\u2010week evolution of pain with the concomitant use of the ETG, this significant pain reduction occurred earlier from the 4th week and continued to decrease (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.016, <jats:italic>d<\/jats:italic>\u00a0=\u00a01.369). In the group that received the complete multimodal treatment, the greatest significant benefit in increasing quality of life occurred in the physical domain and elevation in resilience with an emphasis on meaning and comprehension domains.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The anthroposophic multimodal treatment group presented both safety and efficacy as an analgesic in the groups that received the nonpharmacological therapies, much earlier when associated with the ETG. The multimodal approach corresponded to the pattern of better efficacy for both pain reduction and improvement in quality of life and resilience.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.1590","type":"journal-article","created":{"date-parts":[[2020,3,12]],"date-time":"2020-03-12T01:53:46Z","timestamp":1583978026000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["A twelve\u2010week, four\u2010arm, randomized, double\u2010blind, placebo\u2010controlled, phase 2 prospective clinical trial to evaluate the efficacy and safety of an anthroposophic multimodal treatment on chronic pain in outpatients with postpolio syndrome"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6700-6488","authenticated-orcid":false,"given":"Ricardo","family":"Ghelman","sequence":"first","affiliation":[{"name":"Department of Neurology Universidade Federal de Sao Paulo S\u00e3o Paulo Brazil"},{"name":"Department of Pediatrics Universidade de S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivete Y.","family":"Akiyama","sequence":"additional","affiliation":[{"name":"Department of Neurology Universidade Federal de Sao Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeria T.","family":"de Souza","sequence":"additional","affiliation":[{"name":"Department of Neurology Universidade Federal de Sao Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jussara","family":"Falc\u00e3o","sequence":"additional","affiliation":[{"name":"Department of Neurology Universidade Federal de Sao Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vera","family":"Orgolini","sequence":"additional","affiliation":[{"name":"Department of Neurology Universidade Federal de Sao Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge K.","family":"Hosomi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Universidade Federal de Sao Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abrah\u00e3o A. 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