{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T07:03:06Z","timestamp":1778742186945,"version":"3.51.4"},"reference-count":57,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,4,18]],"date-time":"2020-04-18T00:00:00Z","timestamp":1587168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871052"],"award-info":[{"award-number":["81871052"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To explore shared brain structural alterations in patients diagnosed with mental disorders who experience own\u2010thought auditory verbal hallucinations (OTAVHs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cohort of 143 first\u2010diagnosis, nonmedicated patients with OTAVHs was enrolled: 25 with schizophrenia (FUSCH\u2010OTAVH), 20 with major depression disorder (FUMDD\u2010OTAVH), 28 with bipolar disorder (FUBD\u2010OTAVH), 22 patients with posttraumatic stress disorder (FUPTSD\u2010OTAVH), 21 with anxiety disorder (FUAD\u2010OTAVH), and 27 with borderline personality disorder (FUBPD\u2010OTAVH); 25 healthy controls (HCs) participated. The Auditory Hallucinations Rating Scale (AHRS), multiple psychometric scales, voxel\u2010based morphometry (VBM), tract\u2010based spatial statistics (TBSS), and multiple regression were used.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared with HCs, patients had increased occipital cortex, dorsal prefrontal cortex (PFC), and striatum gray matter volumes (GMVs), a reduced insular cortex (IC) GMV, and an impaired frontooccipital fasciculus. The following differences were found versus HCs: FUSCH\u2010OTAVH, reduced PFC and occipital GMVs, increased striatum and thalamus GMVs, impaired arcuate fasciculus, u\u2010shaped bundle, optic tract, and upper longitudinal fasciculus (LF); FUMDD\u2010OTAVH, increased posterior frontotemporal junction and hippocampus GMVs; FUMN\u2010OTAVH, increased posterior frontotemporal junction and parietal cortex GMVs, reduced hippocampus GMV, impaired upper LF; FUPTSD\u2010OTAVH, increased temporal, hippocampus, and nucleus accumbens GMVs; FUBPD\u2010OTAVH, increased frontotemporal junction and hippocampus GMVs, impaired upper\/lower LF; and FUAD\u2010OTAVH, increased frontal and temporal cortex, hippocampus GMVs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The present findings provide evidence consistent with a bottom\u2010up and top\u2010down reciprocal action dysfunction hypothesis of AVHs and with the dopamine hypothesis of AVHs. We observed specific features related to OTAVHs in patients with different mental disorders. The findings, though complex, provide clues for further studies of specific mental disorders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.1614","type":"journal-article","created":{"date-parts":[[2020,4,18]],"date-time":"2020-04-18T09:04:36Z","timestamp":1587200676000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A unified model of shared brain structural alterations in patients with different mental disorders who experience own\u2010thought auditory verbal hallucinations\u2014A pilot study"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3793-550X","authenticated-orcid":false,"given":"Chuanjun","family":"Zhuo","sequence":"first","affiliation":[{"name":"Department of Biological Psychiatry School of Mental Health Jining Medical University Jining China"},{"name":"The First Affiliated Hospital Zhengzhou University Zhengzhou China"},{"name":"Biological 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