{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T16:18:47Z","timestamp":1783441127159,"version":"3.54.6"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009347","name":"Instituto Nacional de Psiquiatr\u00eda Ram\u00f3n de la Fuente Mu\u00f1iz","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Patterns of altered cerebral perfusion and cognitive dysfunction have been described in Bipolar Disorder (BD) acute episodes and euthymia. Knowledge of the relationship between cognitive function and perfusion in a manic state and status when followed up is still limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To describe brain perfusion alterations and its relationship with cognitive impairment in patients with BD during manic episodes and after 6\u00a0months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Observational\u2010prospective study in 10 type I BD adults during moderate\u2010severe manic episodes. We assessed sociodemographic data and clinical variables as well as cognitive function through Screening for Cognitive Impairment in Psychiatry (SCIP\u2010S). Finally, we performed a Brain Perfusion SPECT using a Tc99m\u2010ethyl cysteine dimer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      During manic episodes, patients showed cognitive impairment with a mean SCIP\u2010S score of 63.8\u00a0\u00b1\u00a017.16. This was positively correlated with perfusion measured as relative reuptake index (RRI) at the right temporal pole (\n                      <jats:italic>\u03c1<\/jats:italic>\n                      \u00a0=\u00a00.65\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.0435) and negatively correlated with right the orbitofrontal cortex (\n                      <jats:italic>\u03c1<\/jats:italic>\n                      \u00a0=\u00a0\u22120.70\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.0077) and the right subgenual cingulate cortex (\n                      <jats:italic>\u03c1<\/jats:italic>\n                      \u00a0=\u00a0\u22120.70\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.0256). Episode severity measured by the Young Mania Rating Scale (YMRS) positively correlated with RRI at the right temporal pole (\n                      <jats:italic>\u03c1<\/jats:italic>\n                      \u00a0=\u00a00.75,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.01). At follow\u2010up, six patients were taking treatment and were euthymic, we found a negative correlation with the YMRS and RRI at the bilateral orbitofrontal cortex (\n                      <jats:italic>\u03c1<\/jats:italic>\n                      \u00a0=\u00a0\u22120.8827,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.019). They did not show significant improvement in cognitive performance at SCIP\u2010S, and there was negative correlation with the following of the SCIP\u2010S subscales; processing speed with the bilateral dorsolateral prefrontal, the bilateral medial prefrontal, the left temporal pole cortex RRI, and verbal fluency with the bilateral anterior cingulate cortex RRI.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Cognitive impairment was correlated with brain perfusion patterns at baseline and follow\u2010up. Large sample size studies with longer follow\u2010up are needed to describe the changes in perfusion and cognitive functions in BD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.1615","type":"journal-article","created":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T07:41:28Z","timestamp":1588318888000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Brain perfusion during manic episode and at 6\u2010month follow\u2010up period in bipolar disorder patients: Correlation with cognitive functions"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2442-652X","authenticated-orcid":false,"given":"Maria Anayali","family":"Estudillo\u2010Guerra","sequence":"first","affiliation":[{"name":"Cl\u00ednica de Trastornos de Afecto National Institute of Psychiatry \u201cRam\u00f3n de la Fuente Mu\u00f1iz\u201d M\u00e9xico City M\u00e9xico"},{"name":"Department of Physical Medicine and Rehabilitation Spaulding Rehabilitation Hospital Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7166-2816","authenticated-orcid":false,"given":"Kevin","family":"Pacheco\u2010Barrios","sequence":"additional","affiliation":[{"name":"Neuromodulation Center and Center for Clinical Research Learning Spaulding Rehabilitation Hospital and Massachusetts General Hospital Boston MA USA"},{"name":"San Ignacio de Loyola University Lima Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8464-6866","authenticated-orcid":false,"given":"Alejandra","family":"Cardenas\u2010Rojas","sequence":"additional","affiliation":[{"name":"Neuromodulation Center and Center for Clinical Research Learning Spaulding Rehabilitation Hospital and Massachusetts General Hospital Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria","family":"Adame\u2010Ocampo","sequence":"additional","affiliation":[{"name":"National Institute of Psychiatry \u201cRam\u00f3n de la Fuente Mu\u00f1iz\u201d Servicio de Neuroimagen M\u00e9xico City M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan A.","family":"Camprodon","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Laboratory for Neuropsychiatry and Neuromodulation Massachusetts General Hospital Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leon","family":"Morales\u2010Quezada","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation Spaulding Rehabilitation Hospital Harvard Medical School Boston MA 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