{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:01:43Z","timestamp":1772118103135,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,4,19]],"date-time":"2020-04-19T00:00:00Z","timestamp":1587254400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31301402"],"award-info":[{"award-number":["31301402"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81671341"],"award-info":[{"award-number":["81671341"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81701333"],"award-info":[{"award-number":["81701333"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Depression is a serious mental illness. However, a significant proportion of patients with depression fail to achieve remission with antidepressant therapies. This study was conducted to explore the antidepressant\u2010like effect of flaxseed oil and flour in an animal model with depression\u2010like behaviors induced by chronic unpredictable stress (CUS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Rats were randomly divided into five groups: normal control (Sham\u2013Sham), CUS plus saline (S\u2010SN), CUS plus escitalopram (S\u2010Esc), CUS plus flaxseeds oil (S\u2010FO), and CUS plus flaxseed flour (S\u2010FF). Behaviors were tested using sucrose preference test and forced swimming test. The serum BDNF concentration, hippocampal BDNF mRNA, and protein expression were measured by enzyme\u2010linked immunosorbent assay, real\u2010time PCR, and Western blot, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The sucrose preference rate was significantly higher in S\u2010FO and S\u2010FF rats than in S\u2010SN and S\u2010Esc rats (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.01), and lower in S\u2010Esc rats than in Sham\u2013Sham rats (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.01). The immobility time was significantly shorter in S\u2010FO and S\u2010FF rats than in S\u2010SN rats (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.01), and shorter in S\u2010Esc rats than in S\u2010SN rats (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.01). Plasma BDNF concentrations were significantly lower in S\u2010FO, S\u2010FF, and S\u2010Esc rats than in Sham\u2013Sham rats (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.01); BDNF was lower in S\u2010FO, S\u2010FF, and S\u2010SN rats than in S\u2010Esc rats. The hippocampal BDNF protein expression was significantly higher in S\u2010Esc rats than in S\u2010SN rats (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.05). The hippocampal BDNF mRNA expression was significantly higher in S\u2010Esc rats than in S\u2010SN rats (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.01). The\n                      <jats:italic>BDNF<\/jats:italic>\n                      gene expression in plasma and the hippocampus negatively correlated with the immobility time (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.05), but\n                      <jats:italic>BDNF<\/jats:italic>\n                      gene expression in the hippocampus positively correlated with the sucrose preference rate (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Flaxseed oil and flaxseed flour exert antidepressant\u2010like effect in rats exposed to chronic stress. Flaxseed may have a therapeutic effect on depression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.1626","type":"journal-article","created":{"date-parts":[[2020,4,19]],"date-time":"2020-04-19T21:15:30Z","timestamp":1587330930000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Antidepressant\u2010like effect of flaxseed in rats exposed to chronic unpredictable stress"],"prefix":"10.1002","volume":"10","author":[{"given":"Yan","family":"Han","sequence":"first","affiliation":[{"name":"Medical Psychological Center The Second Xiangya Hospital Central South University Changsha Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Deng","sequence":"additional","affiliation":[{"name":"Institute of Bast Fiber Crops Chinese Academy of Agricultural Sciences Changsha Hunan China"},{"name":"Key Laboratory of Stem\u2010Fiber Biomass and Engineering Microbiology Ministry of Agriculture Changsha Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Medical Psychological Center The Second Xiangya Hospital Central South University Changsha Hunan China"},{"name":"National Clinical Research Center for Mental Disorders Changsha Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Wang","sequence":"additional","affiliation":[{"name":"Medical Psychological Center The Second Xiangya Hospital Central South University Changsha Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0153-7163","authenticated-orcid":false,"given":"Xiongzhao","family":"Zhu","sequence":"additional","affiliation":[{"name":"Medical Psychological Center The Second Xiangya Hospital Central South University Changsha Hunan China"},{"name":"National Clinical Research Center for Mental Disorders Changsha Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiyong","family":"Mei","sequence":"additional","affiliation":[{"name":"Institute of Bast Fiber Crops Chinese Academy of Agricultural Sciences Changsha Hunan China"},{"name":"Key Laboratory of Stem\u2010Fiber Biomass and Engineering Microbiology Ministry of Agriculture Changsha Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anguo","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Bast Fiber Crops Chinese Academy of Agricultural Sciences Changsha Hunan China"},{"name":"Key Laboratory of Stem\u2010Fiber Biomass and Engineering Microbiology Ministry of Agriculture Changsha Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,4,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.05.045"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2014.04.019"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0046921"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612823666170111141915"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plefa.2006.07.006"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-015-9393-x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2015.09.012"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13197-013-1247-9"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu10101351"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02562226"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2019.04.021"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114510004125"},{"key":"e_1_2_9_14_1","first-page":"18","article-title":"Clinical features of treatment\u2010resistant depression","volume":"62","author":"Kornstein S. 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