{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T15:22:57Z","timestamp":1769095377577,"version":"3.49.0"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,4,19]],"date-time":"2020-04-19T00:00:00Z","timestamp":1587254400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003785","name":"Guangdong Medical Research Foundation","doi-asserted-by":"publisher","award":["A2019442"],"award-info":[{"award-number":["A2019442"]}],"id":[{"id":"10.13039\/501100003785","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Our study aimed to confirm whether coagulation function of patients presenting with intracerebral hemorrhage (ICH) was associated with onset of cerebral microbleeds (CMBs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 174 patients with basal ganglia ICH were divided into CMBs and non\u2010CMBs groups. Indicators of coagulation function and other clinical data that included fibrinogen (FBI), prothrombin time (PT), activated partial thromboplastin time (APTT), and the international normalized ratio (INR) were compared by univariate and multivariate analysis between the two groups. A receiver operating characteristic (ROC) curve was plotted to determine the predictive value of coagulation function indicators for CMBs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Univariate analysis showed that APTT levels was significantly higher in the CMBs group than the non\u2010CMBs group (30.20\u00a0\u00b1\u00a05.18 vs. 27.95\u00a0\u00b1\u00a04.19; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.004), while there was no significant difference between PT, INR, and FBI. The proportion of male patients in the CMBs group was significantly higher than the non\u2010CMBs group (76.58% vs. 52.38%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.001). Multifactor logistic regression analysis demonstrated that APTT and male gender were independent risk factors for CMBs in patients with ICH (OR 1.100, 95% CI: 1.026\u20131.180, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.008; OR 2.957, 95% CI: 1.500\u20135.826, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.002; respectively). ROC curve analysis indicated that the area under the curve of APTT and male gender for CMBs in patients with ICH was 0.641 and 0.621, respectively (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.002 and .008; respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>APTT was an independent risk factor for CMBs in patients with ICH.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.1634","type":"journal-article","created":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T01:13:48Z","timestamp":1587345228000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effect of coagulation function on cerebral microbleeds in intracerebral hemorrhage"],"prefix":"10.1002","volume":"10","author":[{"given":"Hui","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Neurology Shenzhen People\u2019s Hospital The First Affiliated Hospital of Southern University of Science and Technology The Second Clinical Medical College of Jinan University Shenzhen Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Neurology Shenzhen People\u2019s Hospital The First Affiliated Hospital of Southern University of Science and Technology The Second Clinical Medical College of Jinan University Shenzhen Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nianlong","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Radiology Shenzhen Bao\u2010An People\u2019s Hospital Shenzhen Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liangyu","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Neurology Shenzhen People\u2019s Hospital The First Affiliated Hospital of Southern University of Science and Technology The Second Clinical Medical College of Jinan University Shenzhen Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Neurology Shenzhen People\u2019s Hospital The First Affiliated Hospital of Southern University of Science and Technology The Second Clinical Medical College of Jinan University Shenzhen Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Neurology Shenzhen People\u2019s Hospital The First Affiliated Hospital of Southern University of Science and Technology The Second Clinical Medical College of Jinan University Shenzhen Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3399-3144","authenticated-orcid":false,"given":"Yitao","family":"He","sequence":"additional","affiliation":[{"name":"Department of Neurology Shenzhen People\u2019s Hospital The First Affiliated Hospital of Southern University of Science and Technology The Second Clinical Medical College of Jinan University Shenzhen Guangdong 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