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Their global functional connectivity density (gFCD) was screened by functional magnetic resonance imaging (fMRI). Voxel\u2010wise one\u2010way analysis of covariance (ANCOVA) was conducted to detect intergroup differences in gFCD. In a follow\u2010up study, the effects of 5\u00a0weeks of tDCS augmentation treatment on clinical symptoms and gFCD were assessed in the 40 BP patients with AVHs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared to HCs, BP patients with and without AVHs exhibited increased gFCD in the central parietal lobe, insular lobe, and middle cingulate cortex, with decreased gFCD in the posterior parietal cortex, lateral prefrontal cortex, and occipital lobe (all bilateral). Only patients with AVHs showed increased gFCD in the Broca and Wernicke regions, and decreased gFCD in the hippocampus (all bilateral). After 5\u00a0weeks of tDCS, AVHs were slightly alleviated and gFCD abnormalities in the hippocampus were mildly attenuated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients with BP and AVHs showed disturbances in the brain's communication capacity mainly in the left frontoparietal network, control network, and memory circuitry. Five weeks of tDCS alleviated AVHs slightly, without improving depressive symptoms, and attenuated hippocampal gFCD alterations in these patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.1637","type":"journal-article","created":{"date-parts":[[2020,4,18]],"date-time":"2020-04-18T07:13:45Z","timestamp":1587194025000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Global functional connectivity density alterations in patients with bipolar disorder with auditory verbal hallucinations and modest short\u2010term effects of transcranial direct current stimulation augmentation treatment\u2014Baseline and follow\u2010up study"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3793-550X","authenticated-orcid":false,"given":"Chuanjun","family":"Zhuo","sequence":"first","affiliation":[{"name":"School of Mental Health Jining Medical University Jining China"},{"name":"Psychiatric\u2010Neuroimaging\u2010Genetics Laboratory Wenzhou Seventh People's Hospital Wenzhou China"},{"name":"Psychiatric\u2010Neuroimaging\u2010Genetics\u2010Comorbidity Laboratory Tianjin Mental Health Centre Tianjin Anding Hospital Mental Health Teaching Hospital of Tianjin Medical University Tianjin China"},{"name":"Department of Psychiatry First Hospital\/First Clinical Medical College of Shanxi Medical University Taiyuan China"},{"name":"MDT Center for Cognitive Impairment and Sleep Disorders First Hospital of Shanxi Medical University Taiyuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Ji","sequence":"additional","affiliation":[{"name":"School of Mental Health Jining Medical University Jining China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaodong","family":"Lin","sequence":"additional","affiliation":[{"name":"Psychiatric\u2010Neuroimaging\u2010Genetics Laboratory Wenzhou Seventh People's Hospital Wenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongjun","family":"Tian","sequence":"additional","affiliation":[{"name":"Psychiatric\u2010Neuroimaging\u2010Genetics\u2010Comorbidity Laboratory Tianjin Mental Health Centre Tianjin Anding Hospital Mental Health Teaching Hospital of Tianjin Medical University Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina","family":"Wang","sequence":"additional","affiliation":[{"name":"Psychiatric\u2010Neuroimaging\u2010Genetics\u2010Comorbidity Laboratory Tianjin Mental Health Centre Tianjin Anding Hospital Mental Health Teaching Hospital of Tianjin Medical University Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry First Hospital\/First Clinical Medical College of Shanxi Medical University Taiyuan China"},{"name":"MDT Center for Cognitive Impairment and Sleep Disorders First Hospital of Shanxi Medical University Taiyuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenqiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Co\u2010collaboration Laboratory of China and Canada Xiamen Xianyue Hospital and University of Alberta Xiamen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deguo","family":"Jiang","sequence":"additional","affiliation":[{"name":"Psychiatric\u2010Neuroimaging\u2010Genetics Laboratory Wenzhou Seventh People's Hospital Wenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,4,18]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2004.00175.x"},{"key":"e_1_2_10_3_1","first-page":"427","article-title":"The impact of targeted cathodal transcranial direct current stimulation on reward circuitry and affect in bipolar disorder","volume":"44","author":"Bertocci M. 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