{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T21:13:41Z","timestamp":1791580421709,"version":"4.3.4"},"reference-count":39,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,5,13]],"date-time":"2020-05-13T00:00:00Z","timestamp":1589328000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Patients with OCD differ markedly from one another in both number and kind of comorbid disorders. In this study, we set out to identify and characterize homogeneous subgroups of OCD patients based on their comorbidity profile.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In a cohort of 419 adult subjects with OCD, the lifetime presence of fifteen comorbid disorders was assessed. Latent class analysis was used to identify comorbidity\u2010based subgroups. Groups were compared with regard to core clinical characteristics: familiality, childhood trauma, age at onset, illness severity, OCD symptom dimensions, personality characteristics, and course of illness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study sample could be divided in a large group (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0311) with a low amount of comorbidity that could be further subdivided into two subgroups: OCD simplex (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0147) and OCD with lifetime major depressive disorder (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0186), and a group (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0108) with a high amount of comorbidity that could be further subdivided into a general anxiety\u2010related subgroup (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a049), an autism\/social phobia\u2010related subgroup (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a027), and a psychosis\/bipolar\u2010related subgroup (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a010). Membership of the high\u2010comorbid subgroup was associated with higher scores on childhood trauma, illness severity, and the aggression\/checking symptom dimension and lower scores on several personality characteristics.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Grouping OCD patients based on their comorbidity profile might provide more homogeneous, and therefore, more suitable categories for future studies aimed at unraveling the etiological mechanisms underlying this debilitating disorder.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.1641","type":"journal-article","created":{"date-parts":[[2020,5,13]],"date-time":"2020-05-13T20:36:22Z","timestamp":1589402182000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Classification of comorbidity in obsessive\u2013compulsive disorder: A latent class analysis"],"prefix":"10.1002","volume":"10","author":[{"given":"Lucas J. B.","family":"van Oudheusden","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Amsterdam Public Health Amsterdam UMC, Vrije Universiteit Amsterdam Amsterdam The Netherlands"},{"name":"GGZ inGeest Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rens","family":"van de Schoot","sequence":"additional","affiliation":[{"name":"Department of Methods and Statistics Utrecht University Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriaan","family":"Hoogendoorn","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Amsterdam Public Health Amsterdam UMC, Vrije Universiteit Amsterdam Amsterdam The Netherlands"},{"name":"GGZ inGeest Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"van Oppen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Amsterdam Public Health Amsterdam UMC, Vrije Universiteit Amsterdam Amsterdam The Netherlands"},{"name":"GGZ inGeest Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten","family":"Kaarsemaker","sequence":"additional","affiliation":[{"name":"Vincent van Gogh Institute Mental Health Care Centre Noord\u2010 en Midden\u2010Limburg Venray The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerben","family":"Meynen","sequence":"additional","affiliation":[{"name":"GGZ inGeest Amsterdam The Netherlands"},{"name":"Faculty of Humanities VU University Amsterdam Amsterdam The Netherlands"},{"name":"Willem Pompe Institute for Criminal Law and Criminology Utrecht University  The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton J. L. M.","family":"van Balkom","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Amsterdam Public Health Amsterdam UMC, Vrije Universiteit Amsterdam Amsterdam The Netherlands"},{"name":"GGZ inGeest Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,13]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brat.2007.04.003"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2015.06.005"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-009-0922-1"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005653411471"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/da.20026"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291713001591"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/da.22669"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0005-7967(02)00044-X"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000284814"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2019.06.018"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.156.3.379"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1901\/jaba.1998.31-579"},{"key":"e_1_2_11_14_1","unstructured":"First M. B. Spitzer R. L. Gibbon M. &Williams J. B. W.(1999). Structured clinical interview for DSM\u2010IV axis I disorders \u2013 Patient edition (Scid\u2010I\/P Version 2.0). Lisse the Netherlands: Swets & Zeitlinger."},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-014-0510-8"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1989.01810110048007"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0191-8869(98)00245-1"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2016.01.051"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-017-0779-5"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.56.10.921"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/da.20669"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-198907000-00015"},{"key":"e_1_2_11_23_1","first-page":"143","article-title":"The life chart interview: A standardized method to describe the course of psychopathology","volume":"4","author":"Lyketsos C.","year":"1994","journal-title":"International Journal of Methods in Psychiatric Research"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291716003287"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1516-44462008000300003"},{"key":"e_1_2_11_26_1","volume-title":"Mplus user's guide","author":"Muth\u00e9n L. K.","year":"2012"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291708004753"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v63n1207"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/da.20705"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beth.2007.08.004"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v67n0503"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.comppsych.2010.09.006"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2012.04.027"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/mpr.1372"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.genhosppsych.2009.05.002"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0125103"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2015.10.051"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.comppsych.2013.04.013"},{"key":"e_1_2_11_39_1","first-page":"1","article-title":"The GRoLTS\u2010Checklist: Guidelines for reporting on latent trajectory studies","author":"Van de Schoot R.","year":"2016","journal-title":"Structural Equation Modeling"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.58.6.597"}],"container-title":["Brain and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.1641","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/brb3.1641","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.1641","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T05:18:26Z","timestamp":1693631906000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/brb3.1641"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,13]]},"references-count":39,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["10.1002\/brb3.1641"],"URL":"https:\/\/doi.org\/10.1002\/brb3.1641","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/BRB3.1641\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.1641\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.1641\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.1641\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.1641\/v1\/decision1","asserted-by":"object"}]},"ISSN":["2162-3279","2162-3279"],"issn-type":[{"value":"2162-3279","type":"print"},{"value":"2162-3279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,13]]},"assertion":[{"value":"2019-08-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01641"}}