{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T14:58:57Z","timestamp":1772117937878,"version":"3.50.1"},"reference-count":9,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T00:00:00Z","timestamp":1591660800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2019T120284"],"award-info":[{"award-number":["2019T120284"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2018M631964"],"award-info":[{"award-number":["2018M631964"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2016M601451"],"award-info":[{"award-number":["2016M601451"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2017M620119"],"award-info":[{"award-number":["2017M620119"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Few studies of the effect of cardiac abnormalities on acute intracerebral hemorrhage (ICH) outcomes have been published. We sought to determine whether the left ventricular ejection fraction (LVEF) is associated with the functional outcome and mortality of acute ICH patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective study on 364 acute ICH patients from January to December 2016. The primary outcome was defined by the modified Rankin Scale and mortality at 3\u00a0months. The associations between LVEF and outcome were investigated using univariable and multivariable logistic regression models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Depressed LVEF was significantly associated with a poor functional outcome with an odds ratio [OR] of 0.966, 95% confidence interval (CI) 0.942\u20130.991,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.008, and high mortality (OR 0.968 [95% CI 0.943\u20130.994],\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.015) at 3\u00a0months for acute ICH patients by univariate analysis. Multivariable logistic regression analysis indicated that LVEF was an independent predictor of a poor functional outcome (OR 0.961 [95% CI 0.935\u20130.988],\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.005) and mortality (OR 0.949 [95% CI 0.918\u20130.981],\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.002). The percentage of acute ICH patients with poor functional outcome (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.005) and mortality (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.002) was obviously higher in the group of patients with a LVEF of &lt;50%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>LVEF is an independent predictor of functional outcome and mortality at 3\u00a0months for acute ICH patients. These findings could provide the evidence needed for prognosis prediction in acute ICH patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.1643","type":"journal-article","created":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T06:39:20Z","timestamp":1591684760000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Left ventricular ejection fraction as an independent predictor of poor outcome in acute intracerebral hemorrhage"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7173-1914","authenticated-orcid":false,"given":"Guang","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Neurosurgery The First Affiliated Hospital of Harbin Medical University Harbin China"},{"name":"Institute of Brain Science Harbin Medical University Harbin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8346-194X","authenticated-orcid":false,"given":"Lu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Urology The Fourth Hospital of Harbin Medical University Harbin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingxian","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The First Affiliated Hospital of Harbin Medical University Harbin China"},{"name":"Institute of Brain Science Harbin Medical University Harbin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daming","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The First Affiliated Hospital of Harbin Medical University Harbin China"},{"name":"Institute of Brain Science Harbin Medical University Harbin China"},{"name":"Section of Surgical Outcomes and Epidemiology Department of Surgery Yale School of Medicine New Haven Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruotian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The First Affiliated Hospital of Harbin Medical University Harbin China"},{"name":"Institute of Brain Science Harbin Medical University Harbin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Urology The First Affiliated Hospital of Harbin Medical University Harbin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meixin","family":"Long","sequence":"additional","affiliation":[{"name":"Department of Neurology The First Affiliated Hospital of Harbin Medical University Harbin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingqiang","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The First Affiliated Hospital of Harbin Medical University Harbin China"},{"name":"Institute of Brain Science Harbin Medical University Harbin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunmei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology The Fourth Hospital of Harbin Medical University Harbin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoxiong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The First Affiliated Hospital of Harbin Medical University Harbin China"},{"name":"Institute of Brain Science Harbin Medical University Harbin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The First Affiliated Hospital of Harbin Medical University Harbin China"},{"name":"Institute of Brain Science Harbin Medical University Harbin 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