{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T20:13:02Z","timestamp":1790107982090,"version":"4.0.1"},"reference-count":29,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,5,27]],"date-time":"2020-05-27T00:00:00Z","timestamp":1590537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Pharmacodynamics and pharmacogenetics are being explored in pharmacological treatment response for major depressive disorder (MDD). Interactions between genotype and treatment response may be dose dependent. In this study, we examined whether MDD patients with\n                      <jats:italic>Met\/Met, Met\/Val, and Val\/Val COMT<\/jats:italic>\n                      genotypes differed in their response to bupropion in terms of depression scores.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This study utilized a convenience sample of 241 adult outpatients (\u226518\u00a0years) who met DSM\u20105 criteria for MDD and had visits at a Midwest psychopharmacology clinic between February 2016 and January 2017. Exclusion criteria included various comorbid medical, neurological, and psychiatric conditions and current use of benzodiazepines or narcotics. Participants completed genetic testing and the 9 question patient\u2010rated Patient Health Questionnaire (PHQ\u20109) at each clinic visit (\n                      <jats:italic>M<\/jats:italic>\n                      \u00a0=\u00a03.8 visits,\n                      <jats:italic>SD<\/jats:italic>\n                      \u00a0=\u00a01.5) and were prescribed bupropion or another antidepressant drug. All participants were adherent to pharmacotherapy treatment recommendations for &gt;2\u00a0months following genetic testing.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Participants were mostly Caucasian (85.9%) outpatients (154 female and 87 male) who were 44.5\u00a0years old, on average (\n                      <jats:italic>SD<\/jats:italic>\n                      \u00a0=\u00a017.9). For\n                      <jats:italic>Val<\/jats:italic>\n                      carriers, high bupropion doses resulted in significantly lower PHQ\u20109 scores than no bupropion (\n                      <jats:italic>t<\/jats:italic>\n                      (868)\u00a0=\u00a05.04,\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\u00a0.001) or low dose bupropion (\n                      <jats:italic>t<\/jats:italic>\n                      (868)\u00a0=\u00a03.29,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.001).\n                      <jats:italic>Val<\/jats:italic>\n                      carriers differed significantly from\n                      <jats:italic>Met\/Met<\/jats:italic>\n                      patients in response to high dose bupropion (\n                      <jats:italic>t<\/jats:italic>\n                      (868)\u00a0=\u00a0\u22122.03,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.04), but not to low dose bupropion.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      High\u2010dose bupropion is beneficial for MDD patients with\n                      <jats:italic>Met\/Val<\/jats:italic>\n                      or\n                      <jats:italic>Val\/Val COMT<\/jats:italic>\n                      genotypes, but not for patients with\n                      <jats:italic>Met\/Met<\/jats:italic>\n                      genotype. Prospective studies are necessary to replicate this pharmacodynamic relationship between bupropion and\n                      <jats:italic>COMT<\/jats:italic>\n                      genotypes and explore economic and clinical outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.1692","type":"journal-article","created":{"date-parts":[[2020,5,27]],"date-time":"2020-05-27T06:49:03Z","timestamp":1590562143000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The association of\n                    <i>COMT<\/i>\n                    genotype with buproprion treatment response in the treatment of major depressive disorder"],"prefix":"10.1002","volume":"10","author":[{"given":"Jay","family":"Fawver","sequence":"first","affiliation":[{"name":"Parkview Health Parkview Physicians Group (PPG) \u2013 Mind\u2010Body Medicine Fort Wayne IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mindy","family":"Flanagan","sequence":"additional","affiliation":[{"name":"Parkview Mirro Center for Research and Innovation Fort Wayne IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Smith","sequence":"additional","affiliation":[{"name":"Manchester University Fort Wayne IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0010-9260","authenticated-orcid":false,"given":"Michelle","family":"Drouin","sequence":"additional","affiliation":[{"name":"Parkview Mirro Center for Research and Innovation Fort Wayne IN USA"},{"name":"Purdue University Fort Wayne Fort Wayne IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Mirro","sequence":"additional","affiliation":[{"name":"Parkview Mirro Center for Research and Innovation Fort Wayne IN USA"},{"name":"IUPUI School of Informatics and Computing Indianapolis IN USA"},{"name":"Indiana University School of Medicine Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,27]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2005.11.008"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301462"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.2217\/pgs-2018-0142"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32802-7"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2011.03.028"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2011.12.023"},{"key":"e_1_2_11_8_1","volume-title":"Table of Pharmacogenomic Biomarkers in Drug Labeling","author":"FDA","year":"2020"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/YPG.0b013e32833a1f3c"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2005.07.008"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ijnp\/pyv132"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(02)01834-6"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-010-0150-6"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.18m12575"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2012.05.020"},{"issue":"1","key":"e_1_2_11_16_1","first-page":"26","article-title":"Ethnic differences in erythrocyte catechol\u2010O\u2010methyltransferase activity in black and white Americans","volume":"270","author":"McLeod H. 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