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The catechol\u2010O\u2010methyltransferase (<jats:italic>COMT<\/jats:italic>) gene has been known to be associated with suicidal ideation. The present study aimed to explore the relationship of <jats:italic>COMT<\/jats:italic> polymorphism, childhood trauma, and suicidal ideation in patients with PTSD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty patients with PTSD and 62 healthy controls (HCs) were recruited, and <jats:italic>COMT<\/jats:italic> variants rs4680 and rs4633 were genotyped through peripheral blood. Psychological assessments such as the childhood trauma questionnaire (CTQ), the scale for suicidal ideation, the clinician\u2010administered PTSD scale for DSM\u20105, and a PTSD checklist were administered. A regression analysis, the Johnson\u2013Neyman technique, and a two\u2010way analysis of covariance were conducted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Interaction of <jats:italic>COMT<\/jats:italic> polymorphism (rs4680, rs4633) and childhood emotional abuse (subscale of CTQ) predicted suicidal ideation in patients with PTSD. Patients with the rs4680 Val\/Val genotype, compared to Met carriers genotype, showed higher suicidal ideation when childhood emotional abuse was high. Patients with the rs4633 CC genotype, compared to T carriers genotype, showed higher suicidal ideation when childhood emotional abuse was high.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results suggest that vulnerability to suicide could be increased in the Val\/Val genotype of <jats:italic>COMT<\/jats:italic> rs4680 and the CC genotype of rs4633 in patients with PTSD. Moreover, PTSD group with high childhood emotional abuse demonstrated a significantly higher suicidal ideation than did those with low childhood emotional abuse.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.1733","type":"journal-article","created":{"date-parts":[[2020,7,3]],"date-time":"2020-07-03T05:51:08Z","timestamp":1593755468000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Interaction between catechol\u2010O\u2010methyltransferase polymorphism and childhood trauma in suicidal ideation of patients with post\u2010traumatic stress disorder"],"prefix":"10.1002","volume":"10","author":[{"given":"Aeran","family":"Kwon","sequence":"first","affiliation":[{"name":"Clinical Emotion and Cognition Research Laboratory Inje University Goyang Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongil","family":"Min","sequence":"additional","affiliation":[{"name":"Clinical Emotion and Cognition Research Laboratory Inje University Goyang Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yourim","family":"Kim","sequence":"additional","affiliation":[{"name":"Clinical Emotion and Cognition Research Laboratory Inje University Goyang Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min Jin","family":"Jin","sequence":"additional","affiliation":[{"name":"Clinical Emotion and Cognition Research Laboratory Inje University Goyang Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0305-3709","authenticated-orcid":false,"given":"Seung\u2010Hwan","family":"Lee","sequence":"additional","affiliation":[{"name":"Clinical Emotion and Cognition Research Laboratory Inje University Goyang Korea"},{"name":"Department of Psychiatry Inje University, Ilsan Paik Hospital Goyang Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,7,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2018.02.060"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-244X-8-48"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.30541"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/gbb.12090"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-19040-z"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.03.078"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psc.2008.02.002"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2006.10.001"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0023451"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2005.01.026"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2018.04.059"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2010.09081247"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001808"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1037\/1082-989X.1.1.16"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000007994"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2018.03.014"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.286.24.3089"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2008.00635.x"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/1077559507307837"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2015.17.2\/jflory"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2014.10.034"},{"key":"e_1_2_9_23_1","volume-title":"Introduction to mediation, moderation, and conditional process analysis","author":"Hayes A. 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