{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T01:32:47Z","timestamp":1777426367291,"version":"3.51.4"},"reference-count":54,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,7,12]],"date-time":"2020-07-12T00:00:00Z","timestamp":1594512000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["18511108300"],"award-info":[{"award-number":["18511108300"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["18441903903900"],"award-info":[{"award-number":["18441903903900"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["18441903800"],"award-info":[{"award-number":["18441903800"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Numerous treatments suggest that brain plasticity changes after peripheral nerve injury (PNI), and most studies examining functional magnetic resonance imaging focused on abnormal changes in specific brain regions. However, it is the large\u2010scale interaction of neuronal networks instead of isolated brain regions contributed to the functional recovery after PNI. In the present study, we examined the intra\u2010 and internetworks alterations between the related functional resting\u2010state networks (RSNs) in a sciatic nerve injury rat model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Ninety\u2010six female rats were divided into a control and model group. Unilateral sciatic nerve transection and direct anastomosis were performed in the latter group. We used an independent component analysis (ICA) algorithm to observe the changes in RSNs and assessed functional connectivity between different networks using the functional networks connectivity (FNC) toolbox.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Six RSNs related to PNI were identified, including the basal ganglia network (BGN), sensorimotor network (SMN), salience network (SN), interoceptive network (IN), cerebellar network (CN), and default mode network (DMN). The model group showed significant changes in whole\u2010brain FC changes within these resting\u2010state networks (RSNs), but four of these RSNs exhibited a conspicuous decrease. The interalterations performed that significantly decreased FNC existed between the BGN and SMN, BGN and IN, and BGN and DMN (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.05, corrected). A significant increase in FNC existed between DMN and CN and between CN and SN (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.05, corrected).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The results showed the large\u2010scale functional reorganization at the network level after PNI. This evidence reveals new implications to the pathophysiological mechanisms in brain plasticity of PNI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.1747","type":"journal-article","created":{"date-parts":[[2020,7,12]],"date-time":"2020-07-12T23:35:16Z","timestamp":1594596916000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Intra and inter: Alterations in functional brain resting\u2010state networks after peripheral nerve injury"],"prefix":"10.1002","volume":"10","author":[{"given":"Xiang\u2010Xin","family":"Xing","sequence":"first","affiliation":[{"name":"School of Rehabilitation Science Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu\u2010Yun","family":"Hua","sequence":"additional","affiliation":[{"name":"Department of Traumatology and Orthopedics Yueyang Hospital Shanghai University of Traditional Chinese Medicine  Shanghai China"},{"name":"Yangzhi Rehabilitation Hospital Tongji University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mou\u2010Xiong","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Traumatology and Orthopedics Yueyang Hospital Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen\u2010Zhen","family":"Ma","sequence":"additional","affiliation":[{"name":"School of Rehabilitation Science Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bei\u2010Bei","family":"Huo","sequence":"additional","affiliation":[{"name":"School of Rehabilitation Science Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia\u2010Jia","family":"Wu","sequence":"additional","affiliation":[{"name":"Center of Rehabilitation Medicine Yueyang Hospital Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu\u2010Jie","family":"Ma","sequence":"additional","affiliation":[{"name":"School of Rehabilitation Science Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Ma","sequence":"additional","affiliation":[{"name":"School of Rehabilitation Science Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0601-3403","authenticated-orcid":false,"given":"Jian\u2010Guang","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Rehabilitation Science Shanghai University of Traditional Chinese Medicine  Shanghai China"},{"name":"Center of Rehabilitation Medicine Yueyang Hospital Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,7,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/SAP.0000000000001357"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1744-8069-9-21"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-30961-1"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2017.00685"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0025701"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1162\/neco.1995.7.6.1129"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(97)00090-5"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2007.10.013"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3171\/2016.12.FOCUS16430"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.01.090"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncir.2019.00051"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.1048"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-015-1482-4"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.11.001"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsm.2008.048231"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1162\/netn_a_00063"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2012.07.056"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2008.05566.x"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8BM00260F"},{"key":"e_1_2_10_21_1","first-page":"1","article-title":"Brain functional network abnormality extends beyond the sensorimotor network in brachial plexus injury patients","volume":"10","author":"Feng J. T.","year":"2015","journal-title":"Brain Imaging & Behavior"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2013.01.003"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2016.06.018"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2201"},{"key":"e_1_2_10_25_1","first-page":"101937","article-title":"In search of multimodal brain alterations in Alzheimers and Binswangers disease","volume":"20","author":"Fu Z.","year":"2019","journal-title":"NeuroImage Clinical"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/698256"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1868-09.2009"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-018-0638-z"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00141.2010"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2007.08.001"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0707210"},{"issue":"3","key":"e_1_2_10_32_1","first-page":"1","article-title":"A CCA and ICA\u2010based mixture model for identifying major depression disorder","volume":"36","author":"Lin W.","year":"2016","journal-title":"IEEE Transactions on Medical Imaging"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0025701"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06976"},{"key":"e_1_2_10_35_1","first-page":"675","article-title":"Supplementary motor area deactivation impacts the recovery of hand function from severe peripheral nerve injury","volume":"11","author":"Lu Y. C.","year":"2016","journal-title":"Neural Regeneration Research"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1517\/14712598.2011.628933"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1227\/NEU.0000000000000851"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2018.03.003"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/23281"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2003778"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2015.08.004"},{"issue":"2","key":"e_1_2_10_42_1","first-page":"538","article-title":"A stereotaxic MRI template set for the rat brain with tissue class distribution maps and co\u2010registered anatomical atlas: Application to pharmacological","volume":"32","author":"Schwarz A. J.","year":"2006","journal-title":"MRI"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2019.02.005"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0120345"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0025031"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(96)80028-6"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp231"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-012-0451-0"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201506035"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1113455109"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.26478"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.12.024"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2010.07.020"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/7235808"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2018.04.009"}],"container-title":["Brain and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbrb3.1747","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.1747","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/brb3.1747","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.1747","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T02:13:09Z","timestamp":1693534389000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/brb3.1747"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,12]]},"references-count":54,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["10.1002\/brb3.1747"],"URL":"https:\/\/doi.org\/10.1002\/brb3.1747","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/BRB3.1747\/v3\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.1747\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.1747\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.1747\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.1747\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.1747\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.1747\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.1747\/v3\/response1","asserted-by":"object"}]},"ISSN":["2162-3279","2162-3279"],"issn-type":[{"value":"2162-3279","type":"print"},{"value":"2162-3279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,12]]},"assertion":[{"value":"2020-01-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01747"}}