{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:27:29Z","timestamp":1791260849607,"version":"4.1.0"},"reference-count":54,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,9,18]],"date-time":"2020-09-18T00:00:00Z","timestamp":1600387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Epidemiological evidence indicated a relationship between vitamin D (VD) and depression with anxiety, but their therapeutic relationship has not been fully elucidated. This study aimed to examine whether VD supplementation would relieve symptoms in patients with depression and anxiety with low serum 25\u2010hydroxy VD [25(OH) D] levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      Participants with low 25(OH)D levels were randomized to control or daily VD group and were followed up for 6\u00a0months. Serum concentrations of 25(OH) D were measured using commercial kits. Psychological symptoms were evaluated with the Hamilton Depression Rating Scale\u201017 (HAMD\u201017), Revised Social Anhedonia Scale (RSAS), Revised Physical Anhedonia scale (RPAS), and Hamilton Anxiety Rating Scale\u201014 (HAMA\u201014). The trial was listed in the trial registration (\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.medresman.org.cn\/uc\/index.aspx\">http:\/\/www.medresman.org.cn\/uc\/index.aspx<\/jats:ext-link>\n                      ; NTR number: ChiCTR2000030130).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In this clinical population, no significant difference in depression symptoms was detected between VD group and control group at both baseline and at the endpoint of our study. The HAMD\u201017, RSAS, and RPAS scores did not change significantly between VD and control groups from baseline to endpoint (all\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&gt;\u00a0.05). However, there was a significant difference in time effect of the total HAMA\u201014 scores between the two groups (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      [95% Cl]\u00a0=\u00a0\u22122.235 [\u22123.818, \u22120.653],\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.006).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Vitamin D supplementation could improve the anxiety symptoms but not depressive symptoms in depressive patients with low VD level after the 6\u2010month intervention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.1760","type":"journal-article","created":{"date-parts":[[2020,9,18]],"date-time":"2020-09-18T09:36:43Z","timestamp":1600421803000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["Vitamin D supplementation improves anxiety but not depression symptoms in patients with vitamin D deficiency"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1779-9547","authenticated-orcid":false,"given":"Cuizhen","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Sleep Disorders Affiliated Psychological Hospital of Anhui Medical University  Hefei China"},{"name":"Hefei Fourth People's Hospital  Hefei China"},{"name":"Anhui Mental Health Center  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Sleep Disorders Affiliated Psychological 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