{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T19:23:43Z","timestamp":1781897023448,"version":"3.54.5"},"reference-count":47,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,8,30]],"date-time":"2020-08-30T00:00:00Z","timestamp":1598745600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The smell of cannabis is a cue with universal relevance to cannabis users. However, most cue reactivity imaging studies have solely utilized visual images, auditory imagery scripts, or tactile cues in their experiments. This study introduces a multimodal cue reactivity paradigm that includes picture, odor, and bimodal picture\u00a0+\u00a0odor cues.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010eight adults at risk for cannabis use disorder (CUD; defined as at least weekly use and Substance Involvement Score of \u22654 on the Cannabis sub\u2010test of the Alcohol, Smoking and Substance Involvement Screening Test) and 26 cannabis\u2010naive controls were exposed to cannabis and floral cues during event\u2010related fMRI. Between\u2010group differences in fMRI activation and correlations were tested using FMRIB\u2019s Local Analyses of Mixed Effects and corrected for multiple comparisons using a voxelwise threshold of <jats:italic>z<\/jats:italic>\u00a0&gt;\u00a02.3 and a corrected cluster threshold of <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both visual and olfactory modalities resulted in significant activation of craving and reward systems, with cannabis odor cues eliciting a significantly greater response in regions mediating anticipation and reward (nucleus accumbens, pallidum, putamen, and anterior insular cortex, supplementary motor area, angular gyrus and superior frontal gyrus) and cannabis picture cues eliciting a significantly greater response in the occipital cortex and amygdala. Furthermore, the CUD group showed significantly increased activation in the ventral tegmental area (VTA), the insula, and the pallidum compared to controls. Within the CUD group, activation in the insula, anterior cingulate, and occipital cortex to bimodal cannabis cues was significantly correlated with self\u2010reported craving.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our multimodal cue reactivity paradigm is sensitive to neural adaptations associated with problematic cannabis use.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.1764","type":"journal-article","created":{"date-parts":[[2020,8,30]],"date-time":"2020-08-30T15:54:23Z","timestamp":1598802863000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["FMRI activation to cannabis odor cues is altered in individuals at risk for a cannabis use disorder"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4417-4224","authenticated-orcid":false,"given":"Natalia M.","family":"Kleinhans","sequence":"first","affiliation":[{"name":"Department of Radiology 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