{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T04:34:46Z","timestamp":1792816486503,"version":"4.5.0"},"reference-count":35,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,7,23]],"date-time":"2020-07-23T00:00:00Z","timestamp":1595462400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The extracellular matrix (ECM) provides structural support for neuronal, glial, and vascular components of the brain, and regulates intercellular signaling required for cellular morphogenesis, differentiation and homeostasis. We hypothesize that the pathophysiology of diffuse brain injury impacts the ECM in a multi\u2010dimensional way across brain regions and over time, which could facilitate damage and repair processes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Experimental diffuse TBI was induced in male Sprague\u2010Dawley rats (325\u2013375\u00a0g) by midline fluid percussion injury (FPI); uninjured sham rats serve as controls. Tissue from the cortex, thalamus, and hippocampus was collected at 15\u00a0min, 1, 2, 6, and 18\u00a0hr postinjury as well as 1, 3, 7, and 14\u00a0days postinjury. All samples were quantified by Western blot for glycoproteins: fibronectin, laminin, reelin, and tenascin\u2010C. Band intensities were normalized to sham and relative to \u03b2\u2010actin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In the cortex, fibronectin decreased significantly at 15\u00a0min, 1\u00a0hr, and 2\u00a0hr postinjury, while tenascin\u2010C decreased significantly at 7 and 14\u00a0days postinjury. In the thalamus, reelin decreased significantly at 2\u00a0hr, 3 and 14\u00a0days postinjury. In the hippocampus, tenascin\u2010C increased significantly at 15\u00a0min and 7\u00a0days postinjury.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Acute changes in the levels of these glycoproteins suggest involvement in circuit dismantling, whereas postacute levels may indicate a restorative or regenerative response associated with recovery from TBI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.1767","type":"journal-article","created":{"date-parts":[[2020,7,24]],"date-time":"2020-07-24T01:22:07Z","timestamp":1595553727000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Extracellular matrix proteins are time\u2010dependent and regional\u2010specific markers in experimental diffuse brain injury"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6558-261X","authenticated-orcid":false,"given":"Daniel R.","family":"Griffiths","sequence":"first","affiliation":[{"name":"BARROW Neurological Institute at Phoenix Children\u2019s Hospital Phoenix AZ USA"},{"name":"Department of Child Health University of Arizona College of Medicine \u2010 Phoenix Phoenix AZ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taylor M.","family":"Jenkins","sequence":"additional","affiliation":[{"name":"Department of Child Health University of Arizona College of Medicine \u2010 Phoenix Phoenix AZ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline P.","family":"Addington","sequence":"additional","affiliation":[{"name":"School of Biological and Health Systems Engineering, Ira A. Fulton Schools of Engineering Arizona State University Tempe AZ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3606-026X","authenticated-orcid":false,"given":"Sarah E.","family":"Stabenfeldt","sequence":"additional","affiliation":[{"name":"School of Biological and Health Systems Engineering, Ira A. Fulton Schools of Engineering Arizona State University Tempe AZ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4398-6493","authenticated-orcid":false,"given":"Jonathan","family":"Lifshitz","sequence":"additional","affiliation":[{"name":"BARROW Neurological Institute at Phoenix Children\u2019s Hospital Phoenix AZ USA"},{"name":"Department of Child Health University of Arizona College of Medicine \u2010 Phoenix Phoenix AZ USA"},{"name":"Phoenix VA Health Care System Phoenix AZ 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