{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:31:48Z","timestamp":1788481908899,"version":"build-2803163510"},"reference-count":63,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,8,19]],"date-time":"2020-08-19T00:00:00Z","timestamp":1597795200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Autism spectrum disorder (ASD) is a complex and prevalent neurodevelopmental disorder characterized by deficits in social communication and social interaction as well as repetitive behaviors. Alterations in function connectivity are widely recognized in recent electroencephalogram (EEG) studies. However, most studies have not reached consistent conclusions, which could be due to the developmental nature and the heterogeneity of ASD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Here, EEG coherence analysis was used in a cohort of children with ASD (<jats:italic>n<\/jats:italic>\u00a0=\u00a013) and matched typically developing controls (TD, <jats:italic>n<\/jats:italic>\u00a0=\u00a015) to examine the functional connectivity characteristics in long\u2010distance and short\u2010distance electrode pairs. Subsequently, we explore the association between the connectivity strength of coherence and symptom severity in children with ASD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with TD group, individuals with ASD showed increased coherence in short\u2010distance electrode pairs in the right temporal\u2013parietal region (delta, alpha, beta bands), left temporal\u2013parietal region (all frequency bands), occipital region (theta, alpha, beta bands), right central\u2013parietal region (delta, alpha, beta bands), and the prefrontal region (only beta band). In the long\u2010distance coherence analysis, the ASD group showed increased coherence in bilateral frontal region, temporal region, parietal region, and frontal\u2013occipital region in alpha and beta bands. The strength of such connections was associated with symptom severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Our study indicates that abnormal connectivity patterns in neuroelectrophysiology may be of critical importance to acknowledge the underlying brain mechanism.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.1796","type":"journal-article","created":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T07:22:25Z","timestamp":1598599345000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Increased EEG coherence in long\u2010distance and short\u2010distance connectivity in children with autism spectrum disorders"],"prefix":"10.1002","volume":"10","author":[{"given":"Jia","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Children\u2019s and Adolescent Health Public Health College of Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Children\u2019s and Adolescent Health Public Health College of Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuelai","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Developmental and Behavioral Pediatrics Shanghai Children's Medical Center Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Children\u2019s and Adolescent Health Public Health College of Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Heilongjiang Province Center for Disease Control and Prevention  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Children\u2019s and Adolescent Health Public Health College of Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Children\u2019s and Adolescent Health Public Health College of Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0631-5076","authenticated-orcid":false,"given":"Lijie","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Children\u2019s and Adolescent Health Public Health College of Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"crossref","first-page":"pp. 31","DOI":"10.1176\/appi.books.9780890425596","volume-title":"Diagnostic and statistical manual of mental disorders fifth edition (DSM\u20105)","author":"American Psychiatric Association","year":"2013"},{"issue":"9","key":"e_1_2_8_3_1","first-page":"2583","article-title":"Abnormal fronto\u2010parietal coupling of brain rhythms in mild Alzheimer's disease: A multicentric EEG study","volume":"19","author":"Babiloni C.","year":"2004","journal-title":"Federation of European N Euroscience Societies"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.ss6706a1"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005653411471"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2010.11.024"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3340-04.2004"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1099745"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2002.1099"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/aur.1367"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2014.00070"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1037\/0894-4105.21.1.74"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410220408"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2008.01.013"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/10874200802398824"},{"key":"e_1_2_8_16_1","volume-title":"The social responsiveness scale","author":"Constantino J. 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