{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:02:02Z","timestamp":1772118122561,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,8,29]],"date-time":"2020-08-29T00:00:00Z","timestamp":1598659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Diffusion\u2010weighted imaging (DWI) can reflect histopathologic changes in muscle disorders. The present study sought to elucidate possible associations between histopathology derived from muscle biopsies and DWI in myositis and other myopathies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Nineteen patients (10 women, 52.6%) with a mean age 51.43\u00a0\u00b1\u00a019\u00a0years were included in this retrospective study. Apparent diffusion coefficients (ADC) were evaluated with a histogram approach of the biopsied muscle. The histopathology analysis included the scoring systems proposed by Tateyama et al., Fanin et al., Allenbach et al. and immunhistochemical stainings for MHC, CD68, CD8, and CD4.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There was a tendency that skewness was lowered with increasing Tateyama score, but it did not reach statistical significance (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.14). No statistical differences for the other scores were identified. There was a tendency that kurtosis was higher in MHC negative stained patient compared to positive patients, but statistically significance was not reached (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.07). ADC histogram parameters did not correlate with CD68 and CD8 positive stained cells. There was a trend for skewness to correlate with the amount of CD4\u2010positive cells (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a0.57,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.07).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The present study could not identify statistical significant associations between DWI and histopathology in muscle diseases based upon a small patient sample. Presumably, the investigated histopathology scores are more specific for certain disease aspects, whereas ADC values reflect the whole cellularity of the investigated muscle, which might cause the negative results.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.1809","type":"journal-article","created":{"date-parts":[[2020,8,29]],"date-time":"2020-08-29T06:41:27Z","timestamp":1598683287000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Associations between apparent diffusion coefficient values and histopathological tissue alterations in myopathies"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8489-706X","authenticated-orcid":false,"given":"Hans\u2010Jonas","family":"Meyer","sequence":"first","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology University of Leipzig  Leipzig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilka","family":"Schneider","sequence":"additional","affiliation":[{"name":"Department of Neurology Martin\u2010Luther\u2010University Halle\u2010Wittenberg  Halle Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Emmer","sequence":"additional","affiliation":[{"name":"Department of Neurology Martin\u2010Luther\u2010University Halle\u2010Wittenberg  Halle Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malte","family":"Kornhuber","sequence":"additional","affiliation":[{"name":"Department of Neurology Martin\u2010Luther\u2010University Halle\u2010Wittenberg  Halle Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexey","family":"Surov","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology University of Magdeburg  Magdeburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,8,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2009.080422"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-011-2359-0"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.25099"},{"key":"e_1_2_10_5_1","first-page":"740","article-title":"Diffusion\u2010weighted imaging in musculoskeletal radiology\u2010clinical applications and future directions","volume":"5","author":"Bhojwani N.","year":"2015","journal-title":"Quantitative Imaging in Medicine and Surgery"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lpm.2011.01.005"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1402225"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.26373"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.115.163972"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/2058460116668216"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2007.050328"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.22388"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2014.512"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.168.2.3393671"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-016-8350-6"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12524"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20170900"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.958"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2018.09.008"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.24905"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2018.07.013"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20180291"},{"key":"e_1_2_10_23_1","article-title":"Associations between histogram analysis parameters derived from morphological sequences and histopathological tissue alterations in myositis and other myopathies: A preliminary study","author":"Meyer H. 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