{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T19:15:08Z","timestamp":1773429308435,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T00:00:00Z","timestamp":1598572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>While there have been disagreements concerning whether obesity and increase in body weight elevate the risk of dementia, variability in body weight has been recently recognized as a new biometric associated with a high risk for a number of diseases. This nationwide, population\u2010based cohort study examined the association between body weight variability and dementia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 2,812,245 adults (mean age, 51.7\u00a0years; standard deviation, 8.6) without a history of dementia who underwent at least three health examinations between 2005 and 2012 in a nationwide cohort were followed\u2010up until the date of dementia diagnosis (based on prescribed drugs and disease code) or until 2016 (median follow\u2010up duration, 5.38\u00a0years; interquartile range, 5.16\u20135.61). Cox regression models were used to evaluate the risk of Alzheimer's disease and vascular dementia according to body weight variability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The hazard ratios (95% confidence intervals) of the highest quartiles of variability were 1.42 (1.35\u20131.49) for Alzheimer's disease and 1.47 (1.32\u20131.63) for vascular dementia compared to the lowest quartile group as a reference. This association was consistent in various subgroup analyses and sensitivity analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Body weight variability could predict Alzheimer's disease and vascular dementia, which may provide new insights into the prevention and management of dementia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.1811","type":"journal-article","created":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T14:35:05Z","timestamp":1598625305000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Variability in body weight precedes diagnosis in dementia: A nationwide cohort study"],"prefix":"10.1002","volume":"10","author":[{"given":"Jane","family":"Ha","sequence":"first","affiliation":[{"name":"Department of Medicine Korea University College of Medicine Seoul Korea"},{"name":"Center for Obesity and Metabolic Diseases Korea University Anam Hospital Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4432-7403","authenticated-orcid":false,"given":"Yeongkeun","family":"Kwon","sequence":"additional","affiliation":[{"name":"Center for Obesity and Metabolic Diseases Korea University Anam Hospital Seoul Korea"},{"name":"Division of Foregut Surgery Korea University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye\u2010Ji","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Neurology Korea University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DaHye","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biostatistics College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyungdo","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Biostatistics College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mi","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Food Science Norwegian University of Science and Technology Trondheim Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sungsoo","family":"Park","sequence":"additional","affiliation":[{"name":"Center for Obesity and Metabolic Diseases Korea University Anam Hospital Seoul Korea"},{"name":"Division of Foregut Surgery Korea University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ga Eun","family":"Nam","sequence":"additional","affiliation":[{"name":"Department of Family Medicine Korea University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Family Medicine Korea University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Do Hoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Family Medicine Korea University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong Gyu","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Biostatistics College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyung\u2010Hwan","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Family Medicine Korea University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,8,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dadm.2017.05.007"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2015.02.003"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2001.138"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0000000000000005"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000176061.33817.90"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/56.2.320"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2011.134"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1997.03540340056033"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a010055"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2004.34"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2008.582"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0800390"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000086680"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/82.2.435"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2008.01.052"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610204000353"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-2495"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181a60a58"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.63.9.1312"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.1997.00196.x"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2017.09.016"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.62.10.1556"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2016.40.1.79"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-013-2548-4"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afv151"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610212001834"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(15)00033-9"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182904cee"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2017.06.2637"},{"key":"e_1_2_10_31_1","first-page":"765","article-title":"Reduced intellectual performance in extreme overweight","volume":"54","author":"S\u00f8rensen T.I.A.","year":"1982","journal-title":"Human Biology"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1994.03510370056032"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a010261"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1998.tb04537.x"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.2174\/156720507780362047"},{"issue":"1","key":"e_1_2_10_36_1","doi-asserted-by":"crossref","first-page":"e13","DOI":"10.1016\/j.jalz.2012.11.006","article-title":"The worldwide economic impact of dementia 2010","volume":"9","author":"Wimo A.","year":"2013","journal-title":"Alzheimer's & Dementia: The Journal of the Alzheimer's Association"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1987.00370100063012"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-150556"}],"container-title":["Brain and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.1811","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/brb3.1811","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.1811","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T06:55:51Z","timestamp":1693205751000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/brb3.1811"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,28]]},"references-count":37,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["10.1002\/brb3.1811"],"URL":"https:\/\/doi.org\/10.1002\/brb3.1811","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/BRB3.1811\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.1811\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.1811\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.1811\/v1\/decision1","asserted-by":"object"}]},"ISSN":["2162-3279","2162-3279"],"issn-type":[{"value":"2162-3279","type":"print"},{"value":"2162-3279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,28]]},"assertion":[{"value":"2020-04-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01811"}}