{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T01:01:53Z","timestamp":1793062913592,"version":"4.5.0"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T00:00:00Z","timestamp":1600300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      This study aimed to differentiate the variations in the clinical characteristics, MRI irregularity, and glucose metabolism on\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010FDG\u2010PET for the differential diagnosis of Parkinson's Disease (PD), MSA with predominant Parkinsonism (MSA\u2010P), and MSA with predominant cerebellar features (MSA\u2010C).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Thirty PD patients, 22 MSA\u2010P patients, and 28 MSA\u2010C patients received an MRI and 20 PD patients, 11 MSA\u2010P patients, and 13 MSA\u2010C patients received\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010FDG\u2010PET.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Firstly, we found that the clinical data presented a tremor at rest, bradykinesia, and postural instability that was predominated in PD (100%), MSA\u2010P (86.4%), and MSA\u2010C (53.6%) patients, respectively. Then, we used MRI analyses and found that putamina atrophy and hyperintensive rim (T\n                      <jats:sub>2<\/jats:sub>\n                      WI) were characteristic features in MSA\u2010P and cerebellar atrophy, the \u201chot cross bun\u201d sign and signal rise in the middle cerebellar peduncle were more obvious in MSA\u2010C. To further explore the distinctions among the 3 diseases, we also used 18F\u2010FDG\u2010PET technology for our examination and found a decrease in glucose metabolism in the parietal area for Parkinson's Disease (PD), in the bilateral putamen for MSA\u2010P, and in the bilateral cerebellum for MSA\u2010C.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      This study identified the distinctive features of the clinic symptoms, MRI irregularity, and glucose metabolism on\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010FDG\u2010PET, which provided a new basis for the differential diagnosis of Parkinson's Disease (PD), MSA with predominant Parkinsonism (MSA\u2010P), and MSA with predominant cerebellar features (MSA\u2010C).\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.1827","type":"journal-article","created":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T08:48:57Z","timestamp":1600332537000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Clinical features, MRI, and 18F\u2010FDG\u2010PET in differential diagnosis of Parkinson disease from multiple system atrophy"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2056-2177","authenticated-orcid":false,"given":"Ping","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Neurology Second Hospital of Tianjin Medical University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benshu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology General Hospital of Tianjin Medical University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine General Hospital of Tianjin Medical University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology Second Hospital of Tianjin Medical University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2018.11.004"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/124.11.2131"},{"key":"e_1_2_9_4_1","first-page":"1375","article-title":"Multiple\u2010system atrophy","volume":"372","author":"Bhatia K. 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