{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:01:41Z","timestamp":1772118101047,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,12,12]],"date-time":"2020-12-12T00:00:00Z","timestamp":1607731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873799"],"award-info":[{"award-number":["81873799"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Hemorrhagic transformation (HT) is a complex and multifactorial complication among patients with acute ischemic stroke (AIS), and the inflammatory response has been considered as a risk factor for HT. We aimed to evaluate the stratification of FAR (fibrinogen\u2010to\u2010albumin ratio), an inflammatory biomarker, in HT patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 256 consecutive stroke patients with HT and 256 age\u2010 and gender\u2010matched stroke patients without HT were included in this study. HT during hospitalization was diagnosed by follow\u2010up imaging assessment and was classified into hemorrhagic infarction (HI) and parenchymal hematoma (PH) according to the recommendations of European Cooperative Acute Stroke Study II classification. Blood samples were obtained at admission.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Higher levels of FAR were observed in patients with HT compared with the non\u2010HT group [10.29 (8.39\u201312.95) vs. 8.60 (7.25\u201310.8),\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.001], but no significant difference was found between the PH and HI [10.88 (8.72\u201313.40) vs. 10.13 (8.14\u201312.60),\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&gt;\u00a0.05]. Patients were assigned to groups of high FAR (\u22659.51) and low FAR (&lt;9.51) based on the optimal cut\u2010off value. After adjustment for potential confounders, the high FAR remained independently associated with the increased risk of HT (OR\u00a0=\u00a05.027, 95% CI\u00a0=\u00a05.027 (2.309\u201310.942),\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>High FAR was independently associated with the increased risk of HT after AIS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.1855","type":"journal-article","created":{"date-parts":[[2020,12,12]],"date-time":"2020-12-12T18:36:12Z","timestamp":1607798172000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["High fibrinogen\u2010to\u2010albumin ratio is associated with hemorrhagic transformation in acute ischemic stroke patients"],"prefix":"10.1002","volume":"11","author":[{"given":"Yiting","family":"Ruan","sequence":"first","affiliation":[{"name":"Department of Neurology The First Affiliated Hospital of Wenzhou Medical University Wenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengxiang","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Neurology The First Affiliated Hospital of Wenzhou Medical University Wenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuntao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology The First Affiliated Hospital of Wenzhou Medical University Wenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaying","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Mental Health Mental Health School Wenzhou Medical University Wenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haoran","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Neurology The First Affiliated Hospital of Wenzhou Medical University Wenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qianqian","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Mental Health Mental Health School Wenzhou Medical University Wenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunbin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology The First Affiliated Hospital of Wenzhou Medical University Wenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guiqian","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Neurology The First Affiliated Hospital of Wenzhou Medical University Wenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weilei","family":"He","sequence":"additional","affiliation":[{"name":"Department of Neurology The First Affiliated Hospital of Wenzhou Medical University Wenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5493-4357","authenticated-orcid":false,"given":"Jincai","family":"He","sequence":"additional","affiliation":[{"name":"Department of Neurology The First Affiliated Hospital of Wenzhou Medical University Wenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,12,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000000992"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70055-3"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09522"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2016.5815"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.32.2.553"},{"key":"e_1_2_10_7_1","article-title":"Predictive value of fibrinogen\u2010to\u2010albumin ratio in acute coronary syndrome","author":"\u00c7etin M.","year":"2019","journal-title":"Herz"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-06802-y"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-27856-6"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-008-1024-0"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000504191"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-011-0290-8"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.527804"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1002409"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00029330-200604020-00010"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)08020-9"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-019-05770-5"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2017.5291"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182697e70"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.116.013432"},{"key":"e_1_2_10_21_1","first-page":"46","article-title":"[The prognostic significance of fibrinogen concentration in patients with ischemic stroke without thrombolytic treatment","volume":"110","author":"Kochetov A. G.","year":"2010","journal-title":"Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000133204.81153.AC"},{"issue":"10","key":"e_1_2_10_23_1","first-page":"42","article-title":"[Fibrinogen concentration in the evaluation of safety and efficiency of thrombolytic therapy in patients with ischemic stroke]","volume":"84","author":"Liang O. V.","year":"2012","journal-title":"Terapevticheskii Arkhiv"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-018-4856-x"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.2009.02037.x"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/00207454.2017.1349766"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.01.014"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2017.09.033"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.30.4.761"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2011.07.133"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.510321"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.5607\/en.2017.26.3.151"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn.2018.13"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-016-1006-6"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1515\/rns.2011.028"},{"issue":"1","key":"e_1_2_10_36_1","first-page":"68","article-title":"A study of acute ischaemic stroke with special reference to serum albumin level as an indicator of short term prognosis","volume":"68","author":"Rajmohan P.","year":"2020","journal-title":"The Journal of the Association of Physicians of India"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2009.03438.x"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2008.08.005"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.116.013805"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000126040.99024.cf"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000189721.31432.26"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1159\/000498855"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2019.02.018"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2017.01.091"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S198419"}],"container-title":["Brain and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.1855","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/brb3.1855","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.1855","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T03:54:09Z","timestamp":1693281249000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/brb3.1855"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,12]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1002\/brb3.1855"],"URL":"https:\/\/doi.org\/10.1002\/brb3.1855","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/BRB3.1855\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.1855\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.1855\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.1855\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.1855\/v2\/decision1","asserted-by":"object"}]},"ISSN":["2162-3279","2162-3279"],"issn-type":[{"value":"2162-3279","type":"print"},{"value":"2162-3279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,12]]},"assertion":[{"value":"2020-06-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01855"}}