{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T11:18:34Z","timestamp":1772191114153,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,9,27]],"date-time":"2020-09-27T00:00:00Z","timestamp":1601164800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate predictors of performance changes and their time course in healthy older adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>A post hoc analysis of a RCT investigating the effect of reasoning cognitive training (ReaCT) compared to an active control group (CG) during a time course.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting and participants<\/jats:title>\n                    <jats:p>\n                      An online, home\u2010based RCT including\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a04,310 healthy participants (ReaCT:\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a02,557; CG:\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a01,753) aged 50\u00a0years and older.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Multiple regression analyses were conducted to investigate predictors (age, sex, education, severity of depression, number of training sessions the participants attended, and neuropsychological baseline values) of the outcome measures grammatical reasoning, working memory, digit vigilance, verbal short\u2010term memory, and verbal learning at 6\u00a0weeks, 3, and 6\u00a0months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Being female and lower education predicted improvements in grammatical reasoning scores at 6\u00a0weeks and 3\u00a0months of training.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion and implication<\/jats:title>\n                    <jats:p>Identifying predictors for nonpharmacological interventions may help to set up a personalized medicine approach in order to prevent cognitive decline in healthy older adults.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.1861","type":"journal-article","created":{"date-parts":[[2020,9,27]],"date-time":"2020-09-27T04:46:43Z","timestamp":1601182003000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Predictors of changes after reasoning training in healthy adults"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6015-3194","authenticated-orcid":false,"given":"Mandy","family":"Roheger","sequence":"first","affiliation":[{"name":"Department of Medical Psychology Neuropsychology and Gender Studies &amp; Center for Neuropsychological Diagnostics and Intervention (CeNDI) Faculty of Medicine and University Hospital Cologne  Cologne Germany"},{"name":"Department of Neurology University Medicine Greifswald  Greifswald Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elke","family":"Kalbe","sequence":"additional","affiliation":[{"name":"Department of Medical Psychology Neuropsychology and Gender Studies &amp; Center for Neuropsychological Diagnostics and Intervention (CeNDI) Faculty of Medicine and University Hospital Cologne  Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2015-0316","authenticated-orcid":false,"given":"Anne","family":"Corbett","sequence":"additional","affiliation":[{"name":"Institute of Health Research University of Exeter Medical School University of Exeter  Exeter UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7908-263X","authenticated-orcid":false,"given":"Helen","family":"Brooker","sequence":"additional","affiliation":[{"name":"Institute of Health Research University of Exeter Medical School University of Exeter  Exeter 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