{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T14:53:34Z","timestamp":1781880814086,"version":"3.54.5"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,12,14]],"date-time":"2020-12-14T00:00:00Z","timestamp":1607904000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2016A030313228"],"award-info":[{"award-number":["2016A030313228"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014857","name":"National Natural Science Foundation of China-Guangdong Joint Fund","doi-asserted-by":"publisher","award":["81671182"],"award-info":[{"award-number":["81671182"]}],"id":[{"id":"10.13039\/501100014857","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Studies have demonstrated that antinuclear antibodies (ANAs) may be correlated with neuromyelitis optica spectrum disorder (NMOSD). However, the conflicting results of studies about the value of ANAs in AQP4 antibody\u2010positive NMOSD patients need to be further investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material<\/jats:title>\n                    <jats:p>Case data were collected from 143 patients with AQP4 antibody\u2010positive NMOSD. Patients were divided into two groups based on the ANA test results. The analysis of clinical characteristics, laboratory tests, and MRI examination results were compared between two groups: the NMOSD patients with ANA (+) and with ANA (\u2212).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Disease duration of NMOSD is shorter in the ANA (+) patients with EDSS\u00a0&lt;\u00a04 than in the ANA (\u2212) patients (12.05\u00a0\u00b1\u00a016.73 versus 29.43\u00a0\u00b1\u00a041.03,\n                      <jats:italic>p<\/jats:italic>\n                      \u2010value\u00a0=\u00a0.013). The median time from disease onset to an EDSS score of 4.0 is significantly longer in the ANA (\u2212) NMOSD patients than in the ANA (+) patients (48.2\u00a0months versus 24\u00a0months,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.04). In addition, ANA (RR, 2.234; 95% CI, 1.078\u20134.629;\n                      <jats:italic>p<\/jats:italic>\n                      \u2010value\u00a0=\u00a0.031) can predict the severity of NMOSD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Antinuclear antibodies seem to be associated with more severe disease activity in NMOSD patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.1865","type":"journal-article","created":{"date-parts":[[2020,12,15]],"date-time":"2020-12-15T12:56:14Z","timestamp":1608036974000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Serum antinuclear antibodies associate with worse prognosis in AQP4\u2010positive neuromyelitis optica spectrum disorder"],"prefix":"10.1002","volume":"11","author":[{"given":"Rong","family":"Fan","sequence":"first","affiliation":[{"name":"Department of Neurology and Multiple Sclerosis Research Center The Third Affiliated Hospital Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuefeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology Guangzhou Brain Hospital Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunqi","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurology Nanfang Hospital Southern Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayi","family":"Tong","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Epidemiology and Informatics University of Pennsylvania Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhigang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology The Fifth Affiliated Hospital Sun Yat\u2010sen University Zhuhai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meifeng","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Neurology and Multiple Sclerosis Research Center The Third Affiliated Hospital Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenkui","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Nephrology The Second People's Hospital of Foshan Foshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Epidemiology and Informatics University of Pennsylvania Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuhua","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Neurology and Multiple Sclerosis Research Center The Third Affiliated Hospital Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0040-4211","authenticated-orcid":false,"given":"Ying","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Neurology and Multiple Sclerosis Research Center The Third Affiliated Hospital Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2018-214819"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.wco.0000227032.47458.cb"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2018.00888"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2004.09.003"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000448286"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-017-8676-8"},{"key":"e_1_2_10_8_1","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.4049\/jimmunol.151.3.1614","article-title":"Antigen\u2013specific induction of antibodies against native mammalian DNA in nonautoimmune mice","volume":"151","author":"Desai D. 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