{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T12:20:34Z","timestamp":1790338834993,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CMRPG8J0211"],"award-info":[{"award-number":["CMRPG8J0211"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Obstructive sleep apnea (OSA)\u2010associated hypoxemia, sleep fragmentation, and cerebral vascular dysfunction are implicated in cognitive dysfunction. Functional connectivity within default mode network (DMN) is a possible mechanism underlying the cognitive impairment. The aim of this study was to investigate the impact of hypoxemia and sleep fragmentation on functional connectivity and on cognitive performance in patients with OSA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Twenty\u2010eight patients with OSA were included (mean age\u00a0=\u00a058.0\u00a0\u00b1\u00a08.5\u00a0years). We correlated the functional connectivity in DMN with cognitive performances and further analyzed the relationship of functional connectivity in DMN with hypoxemia severity, as revealed by apnea\u2010hypopnea index (AHI), oxygen desaturation index (ODI), and nadir SaO\n                      <jats:sub>2<\/jats:sub>\n                      (%), and with degree of sleep fragmentation, as shown by sleep efficiency and wake after sleep onset.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Functional connectivity in DMN was associated with AHI, ODI, and nadir SaO\n                      <jats:sub>2<\/jats:sub>\n                      (%) (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.05) and was not associated with sleep fragmentation measures (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&gt;\u00a0.05). Functional connectivity that was associated with AHI, ODI, and nadir SaO\n                      <jats:sub>2<\/jats:sub>\n                      (%) was in the areas of bilateral middle temporal gyri, bilateral frontal pole, and bilateral hippocampus and was positively correlated with Cognitive Abilities Screening Instrument (CASI) total score (\n                      <jats:italic>\u03c1<\/jats:italic>\n                      \u00a0=\u00a00.484;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.012), CASI\u2010List\u2010generating, CASI\u2010Attention, and composite score of CASI\u2010List\u2010generating plus CASI\u2010Attention (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Functional connectivity in DMN is implicated in impairment of global cognitive function and of attention in OSA patients. The functional connectivity in the DMN is associated with hypoxemia rather than with sleep fragmentation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.1889","type":"journal-article","created":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T23:15:37Z","timestamp":1604272537000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Functional connectivity in default mode network correlates with severity of hypoxemia in obstructive sleep apnea"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7560-7224","authenticated-orcid":false,"given":"Ya\u2010Ting","family":"Chang","sequence":"first","affiliation":[{"name":"Department of Neurology Kaohsiung Chang Gung Memorial Hospital Chang Gung University College of Medicine  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yung\u2010Che","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Pulmonary &amp; Critical Care Medicine Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital Chang Gung University College of Medicine  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yung\u2010Lung","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital Chang Gung University College of Medicine  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih\u2010Wei","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Radiology Kaohsiung Chang Gung Memorial Hospital Chang Gung University College of Medicine  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng\u2010Yueh","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurology Kaohsiung Chang Gung Memorial Hospital Chang Gung University College of Medicine  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen\u2010Chang","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Radiology Kaohsiung Chang Gung Memorial Hospital Chang Gung University College of Medicine  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po\u2010Yuan","family":"Hsu","sequence":"additional","affiliation":[{"name":"Division of Pulmonary &amp; Critical Care Medicine Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital Chang Gung University College of Medicine  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng\u2010Chih","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Pulmonary &amp; Critical Care Medicine Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital Chang Gung University College of Medicine  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.10.010"},{"key":"e_1_2_13_3_1","volume-title":"Diagnostic and statistical manual of mental disorders","author":"American Psychiatric Association","year":"1994"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.02.005"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/26.3.298"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(00)01683-0"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1440.011"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-019-0563-3"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsr.12477"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2018.101621"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2018.00363"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00740-2018"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2011.06.024"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2017.06.009"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsmc.2017.09.009"},{"issue":"4","key":"e_1_2_13_16_1","first-page":"S102","article-title":"Cognitive function in the sleep apnea\/hypopnea syndrome (SAHS)","volume":"23","author":"Engleman H. 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