{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:02:05Z","timestamp":1772118125108,"version":"3.50.1"},"reference-count":63,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,10,24]],"date-time":"2020-10-24T00:00:00Z","timestamp":1603497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81601483"],"award-info":[{"award-number":["81601483"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81630104"],"award-info":[{"award-number":["81630104"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Generalized tonic\u2010clonic seizure (GTCS) is a condition that is characterized by generalized spike\u2010wave discharge in bilateral cerebral hemispheres during the seizure. Although previous neuroimaging studies revealed functional abnormalities in the brain activities of children with GTCS, the topological alterations in whole\u2010brain networks remain poorly understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The present study used graph theory to investigate the topological organization of functional networks in 13 GTCS children and 30 age\u2010matched healthy controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We found that both groups exhibited a small\u2010world topology of the functional network. However, children with GTCS showed a significant decrease in nodal local efficiency and clustering coefficient in some key nodes compared with the controls. The connections within the default mode network (DMN) were decreased significantly, and the internetwork connections were increased significantly. The altered topological properties may be an effect of chronic epilepsy. As a result, the optimal topological organization of the functional network was disrupted in the patient group. Notably, clustering coefficient and nodal local efficiency in the bilateral temporal pole of the middle temporal gyrus negatively correlated with the epilepsy duration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These results suggest that the bilateral temporal pole plays an important role in reflecting the effect of chronic epilepsy on the topological properties in GTCS children. The present study demonstrated a disrupted topological organization in children with GTCS. These findings provide new insight into our understanding of this disorder.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.1890","type":"journal-article","created":{"date-parts":[[2020,10,24]],"date-time":"2020-10-24T05:56:03Z","timestamp":1603518963000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Disrupted topological properties of functional networks in epileptic children with generalized tonic\u2010clonic seizures"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0914-6386","authenticated-orcid":false,"given":"Yongxin","family":"Li","sequence":"first","affiliation":[{"name":"Formula\u2010pattern Research Center School of Traditional Chinese Medicine Jinan University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurosurgery Shenzhen Children Hospital Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenhua","family":"Huang","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Medical Biomechanics School of Basic Medical Sciences Southern Medical University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5101-09.2010"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/1073858406293182"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2015.06.005"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhq291"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.01.055"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp028"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.01.026"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2575"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4793-12.2013"},{"issue":"3","key":"e_1_2_10_11_1","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1684\/j.1950-6945.2003.tb00005.x","article-title":"Video\u2010EEG evidence of lateralized clinical features in primary generalized epilepsy with tonic\u2010clonic seizures","volume":"5","author":"Casaubon L.","year":"2003","journal-title":"Epileptic Disorders"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000230171.23913.cf"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1528-1157.2001.10401.x"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e32835ee5b8"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001536"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13670"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.04.087"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.24041"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2005.06.004"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurad.2010.12.007"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.13131638"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2013.11.016"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23323"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0015219"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2017.00374"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.00253"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1089\/brain.2012.0132"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0008525"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23430"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.21286"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.60.10.1365"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1525-5050(02)00029-X"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2013.11.019"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2019.106254"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.10.018"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-10778-0"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13456"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0017294"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0609523103"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3801"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22871"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2011.03121.x"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2010.03.008"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2009.02068.x"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2018.01038"},{"key":"e_1_2_10_46_1","first-page":"386","article-title":"GRETNA: A graph theoretical network analysis toolbox for imaging connectomics","volume":"9","author":"Wang J.","year":"2015","journal-title":"Frontiers in Human Neuroscience"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2017.00209"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000008096"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2010.12.034"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0039701"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2014.03.003"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/30918"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4085-10.2011"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.02.031"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0068910"},{"key":"e_1_2_10_56_1","first-page":"13","article-title":"DPARSF: A MATLAB toolbox for\" pipeline\" data analysis of resting\u2010state fMRI","volume":"4","author":"Yan C.","year":"2010","journal-title":"Frontiers in Systems Neuroscience"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2014.06.010"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.06.041"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2013.10.017"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr223"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22805"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22877"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2011.07.007"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2014.11.014"}],"container-title":["Brain and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.1890","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/brb3.1890","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.1890","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T07:01:33Z","timestamp":1723791693000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/brb3.1890"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,24]]},"references-count":63,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["10.1002\/brb3.1890"],"URL":"https:\/\/doi.org\/10.1002\/brb3.1890","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/BRB3.1890\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.1890\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.1890\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.1890\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.1890\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.1890\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.1890\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.1890\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.1890\/v2\/decision1","asserted-by":"object"}]},"ISSN":["2162-3279","2162-3279"],"issn-type":[{"value":"2162-3279","type":"print"},{"value":"2162-3279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,24]]},"assertion":[{"value":"2020-05-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01890"}}