{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:08:43Z","timestamp":1790622523639,"version":"4.1.0"},"reference-count":79,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,11,27]],"date-time":"2013-11-27T00:00:00Z","timestamp":1385510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      It is well established that individuals exposed to alcohol in utero have reduced cortical grey matter volumes. However, the candidate determinants of these reductions, cortical thickness (\n                      <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>\n                      ) and surface area (\n                      <jats:styled-content style=\"fixed-case\">SA<\/jats:styled-content>\n                      ), have not been investigated exclusively in alcohol\u2010related neurodevelopmental disorder (\n                      <jats:styled-content style=\"fixed-case\">ARND<\/jats:styled-content>\n                      ), the most prevalent fetal alcohol spectrum disorder subgroup that lacks the characteristic facial dysmorphology.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      T1\u2010weighted magnetic resonance imaging scans were obtained from 88 participants (8\u201316\u00a0years), 36 diagnosed with\n                      <jats:styled-content style=\"fixed-case\">ARND<\/jats:styled-content>\n                      and 52 typically developing controls. Scans were submitted to the\n                      <jats:styled-content style=\"fixed-case\">CIVET<\/jats:styled-content>\n                      pipeline (version 1.1.10). Deformable models were used to construct the inner white matter surfaces and pial surfaces from which\n                      <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">SA<\/jats:styled-content>\n                      measures were derived. Group differences in cortical volume,\n                      <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>\n                      , and\n                      <jats:styled-content style=\"fixed-case\">SA<\/jats:styled-content>\n                      were computed using a general linear model covaried for age, sex, and handedness.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Global cortical volume reductions in\n                      <jats:styled-content style=\"fixed-case\">ARND<\/jats:styled-content>\n                      did not reflect\n                      <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>\n                      , which did not differ between groups. Instead, volume decreases were consistent with global\n                      <jats:styled-content style=\"fixed-case\">SA<\/jats:styled-content>\n                      reductions in bilateral frontal and temporal as well as right occipital regions. Local reductions in\n                      <jats:styled-content style=\"fixed-case\">SA<\/jats:styled-content>\n                      were observed in the right superior temporal gyrus and the right occipital\u2010temporal region.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Results suggest that in\n                      <jats:styled-content style=\"fixed-case\">ARND<\/jats:styled-content>\n                      , prenatal alcohol exposure perturbs global\n                      <jats:styled-content style=\"fixed-case\">SA<\/jats:styled-content>\n                      to a greater degree than\n                      <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>\n                      , particularly in the right temporal lobe.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.191","type":"journal-article","created":{"date-parts":[[2013,11,27]],"date-time":"2013-11-27T23:05:09Z","timestamp":1385593509000},"page":"41-50","source":"Crossref","is-referenced-by-count":54,"title":["Cortical morphology in children with alcohol\u2010related neurodevelopmental disorder"],"prefix":"10.1002","volume":"4","author":[{"given":"Meghna","family":"Rajaprakash","sequence":"first","affiliation":[{"name":"Neurosciences and Mental Health Research Program The Hospital for Sick Children Toronto Ontario Canada"},{"name":"Faculty of Medicine University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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