{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T08:58:15Z","timestamp":1776589095760,"version":"3.51.2"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,11,5]],"date-time":"2020-11-05T00:00:00Z","timestamp":1604534400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Not much is known about influenza\u2010associated neurological complications. We aimed to describe the case series of hospitalized patients who were confirmed with influenza A and presented with neurological symptoms in order to capture the broad spectrum of influenza clinical manifestation and suggest including influenza diagnostic in some neurological conditions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>The inclusion criteria were age\u00a0\u2265\u00a018 and laboratory\u2010confirmed influenza presenting with neurological symptoms. Influenza\u2010associated neurological complication was described as a development of neurological symptom with no other origin. The outcomes were classified into 5 categories: 1. recovery with no significant disability; 2. minor disability (able to manage on their own); 3. moderate disability (requiring some help but able to walk without assistance); 4. severe disability (unable to walk without assistance and perform daily activities); 5. death.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 12 patients (five women and seven men) were enrolled, with age range 18\u201371\u00a0years old. Neurological complications of pandemic A(H\n                      <jats:sub>1<\/jats:sub>\n                      N\n                      <jats:sub>1<\/jats:sub>\n                      )2009pdm influenza developed in seven out of 69 (10.1%) hospitalized patients. The most common neurological complication was encephalopathy. Neurological complications developed in two out of 24 (8.3%) hospitalized patients during postpandemic (H\n                      <jats:sub>1<\/jats:sub>\n                      N\n                      <jats:sub>1<\/jats:sub>\n                      )\n                      <jats:sub>V<\/jats:sub>\n                      period. One patient presented with encephalopathy, another with meningoencephalitis. During the 2018 influenza season, there was one patient who has developed influenza A neurological complications. Overall, two out of 104 (1.9%) influenza A patients developed influenza\u2010associated neurological complications in 2019.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Every patient with unexplained neurological symptoms and signs similar to aseptic and septic meningitis\/encephalitis has to be tested for influenza virus during epidemics and pandemics.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.1916","type":"journal-article","created":{"date-parts":[[2020,11,5]],"date-time":"2020-11-05T20:44:28Z","timestamp":1604609068000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Neurological complications of pandemic A(H1N1)2009pdm, postpandemic A(H1N1)v, and seasonal influenza A"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1599-2973","authenticated-orcid":false,"given":"Daiva","family":"Radzi\u0161auskien\u0117","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases and Dermatovenerology Vilnius University  Vilnius Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Vitkauskait\u0117","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Vilnius University  Vilnius Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karolina","family":"\u017dvinyt\u0117","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Vilnius University  Vilnius Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R\u016bta","family":"Mameni\u0161kien\u0117","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery Vilnius University  Vilnius Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,11,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.4172\/2314-7326.1000201"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1515\/med-2016-0064"},{"issue":"1","key":"e_1_2_10_4_1","article-title":"Neurologic complications of acute influenza in adults: Case report and review of the literature","volume":"2","author":"Bengualid V.","year":"2017","journal-title":"Journal of Neuroscience & Clinical Research"},{"issue":"1","key":"e_1_2_10_5_1","first-page":"32","article-title":"Untergruppe \u00abBewertung Blutassoziierter Krankheitserreger\u00bb. 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