{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T11:53:28Z","timestamp":1774266808647,"version":"3.50.1"},"reference-count":59,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T00:00:00Z","timestamp":1605657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>New evidence suggests that the centromedial amygdala (CMA) and the basolateral amygdala (BLA) play different roles in threat processing. Our study aimed to investigate the effects of trauma and post\u2010traumatic stress disorder (PTSD) on the functional connectivity (FC) of the amygdala and its subregions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty\u2010seven patients with typhoon\u2010related PTSD, 33 trauma\u2010exposed controls (TEC), and 30 healthy controls (HC) were scanned with a 3\u2010Tesla magnetic resonance imaging scanner. The FCs of the BLA, the CMA, and the amygdala as a whole were examined using a seed\u2010based approach, and then, the analysis of variance was used to compare the groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We demonstrated that the BLA had a stronger connectivity with the prefrontal cortices (PFCs) and angular gyrus in the PTSD group than in the TEC group. Additionally, compared with the PTSD and the HC groups, the TEC group exhibited decreased and increased BLA FC with the ventromedial PFC and postcentral gyrus (PoCG), respectively. Furthermore, the PTSD group showed abnormal FC between the salience network and default\u2010mode network, as well as the executive control network. Compared with the HC group, the TEC group and the PTSD group both showed decreased BLA FC with the superior temporal gyrus (STG). Finally, the FCs between the bilateral amygdala (as a whole) and the vmPFC, and between the BLA and the vmPFC have a negative correlation with the severity of PTSD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Decreased BLA\u2010vmPFC FC and increased BLA\u2010PoCG FC may reflect PTSD resilience factors. Trauma leads to decreased connectivity between the BLA and the STG, which could be further aggravated by PTSD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.1952","type":"journal-article","created":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T10:33:27Z","timestamp":1605695607000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Altered functional connectivity of the amygdala and its subregions in typhoon\u2010related post\u2010traumatic stress disorder"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8759-0581","authenticated-orcid":false,"given":"Tao","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Neurology Hainan General Hospital (Hainan Hospital Affiliated to Hainan Medical College) Haikou Hainan Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Ke","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging Jinling Hospital Medical School of Nanjing University Nanjing Jiangsu Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rongfeng","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging Jinling Hospital Medical School of Nanjing University Nanjing Jiangsu Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Psychiatry and Mental Health of Hunan Province Mental Health Institute the Second Xiangya Hospital National Technology Institute of Psychiatry Central South University Changsha Hunan Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiqiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging Jinling Hospital Medical School of Nanjing University Nanjing Jiangsu Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging Jinling Hospital Medical School of Nanjing University Nanjing Jiangsu Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Zhong","sequence":"additional","affiliation":[{"name":"School of Psychology Nanjing Normal University Nanjing Jiangsu Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangming","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging Jinling Hospital Medical School of Nanjing University Nanjing Jiangsu Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiology Hainan General Hospital (Hainan Hospital Affiliated to Hainan Medical College) Haikou Hainan Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,11,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2011.04.029"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0903183106"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2013.05.005"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbt165"},{"issue":"3","key":"e_1_2_9_6_1","first-page":"187","article-title":"Alterations in default network connectivity in posttraumatic stress disorder related to early\u2010life trauma","volume":"34","author":"Bluhm R. L.","year":"2009","journal-title":"Journal of Psychiatry and Neuroscience"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1113455109"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2009.05.001"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2013.197"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.9.3.382"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.04.042"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2007.07030504"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0b013e3283300fbc"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2010.04.028"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/da.20208"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2012.08.003"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.09.046"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2003.08.004"},{"issue":"2","key":"e_1_2_9_19_1","first-page":"107","article-title":"A default mode of brain function in altered states of consciousness","volume":"150","author":"Guldenmund P.","year":"2012","journal-title":"Archives Italiennes De Biologie"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1586\/ern.10.198"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2009.09071074"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhq237"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/da.22478"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(98)00282-0"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1025048802629"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2000.0721"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2009.05.020"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2015.79"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2008.03.010"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2012.06.003"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2002.1087"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3339"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2009.104"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.05.028"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2011.00062"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.06.004"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20854"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.11.030"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0058150"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5587-06.2007"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2009.83"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1364.007"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2008.05.027"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2015.8"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1162\/jocn.2008.21029"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0800005105"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1503\/jpn.110069"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2013.05.031"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2012.04.012"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s007010050062"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.08m04754blu"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhn014"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2003.026583"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1999.91.5.0781"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.3171\/JNS-07\/07\/0056"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/da.1029"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.03.004"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/da.22594"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1965.01720310065008"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0033-3182(71)71479-0"}],"container-title":["Brain and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.1952","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/brb3.1952","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.1952","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T03:52:24Z","timestamp":1693281144000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/brb3.1952"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,18]]},"references-count":59,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1002\/brb3.1952"],"URL":"https:\/\/doi.org\/10.1002\/brb3.1952","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/BRB3.1952\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.1952\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.1952\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.1952\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.1952\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.1952\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.1952\/v1\/decision1","asserted-by":"object"}]},"ISSN":["2162-3279","2162-3279"],"issn-type":[{"value":"2162-3279","type":"print"},{"value":"2162-3279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,18]]},"assertion":[{"value":"2020-07-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01952"}}