{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T23:52:30Z","timestamp":1785541950641,"version":"3.56.0"},"reference-count":81,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,12,3]],"date-time":"2020-12-03T00:00:00Z","timestamp":1606953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To identify the most prominent and replicable fractional anisotropy (FA) alterations of white matter associated with obsessive\u2010compulsive disorder (OCD) in tract\u2010based spatial statistics (TBSS) studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We reviewed previous TBSS studies (<jats:italic>n<\/jats:italic>\u00a0=\u00a020) in OCD and performed a meta\u2010analysis (<jats:italic>n<\/jats:italic>\u00a0=\u00a016) of FA differences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No between\u2010group differences in FA were detected in the pooled meta\u2010analysis. However, reduced FA was identified in the genu and anterior body of corpus callosum (CC) in adult OCD. FA reductions in the anterior body of CC were associated with a later age of onset in adult patients with OCD. For pediatric OCD, decreased FA in earlier adolescence and increased FA in later adolescence were seemingly related to an altered trajectory of brain maturation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Absent in the pooled sample but robust in adults, disrupted microstructural organization in the anterior part of CC indicates a bias of deficits toward connections in interhemispheric connections of rostral neocortical regions, which could lead to deficits of interhemispheric communication and thus contribute to cognitive and emotional deficits in adult OCD. The correlation between FA in the anterior body of CC and older illness onset suggests that patients with later adult onset of illness may represent a biologically distinct subgroup. For pediatric OCD, alterations in neurodevelopmental maturation may contribute to inconsistent patterns of FA alteration relative to controls during adolescence. While most studies of OCD have emphasized alterations of within hemisphere fronto\u2010striatal circuits, these results indicate that between hemisphere connectivity of this circuitry may also represent important pathophysiology of the illness.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.1975","type":"journal-article","created":{"date-parts":[[2020,12,3]],"date-time":"2020-12-03T14:32:54Z","timestamp":1607005974000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Microstructural white matter abnormalities in pediatric and adult obsessive\u2010compulsive disorder: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"11","author":[{"given":"Qian","family":"Li","sequence":"first","affiliation":[{"name":"Huaxi MR Research Center (HMRRC), Department of Radiology West China Hospital of Sichuan University Chengdu China"},{"name":"Research Unit of Psychoradiology Chinese Academy of Medical Sciences Chengdu China"},{"name":"Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital of Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youjin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Huaxi MR Research Center (HMRRC), Department of Radiology West China Hospital of Sichuan University Chengdu China"},{"name":"Research Unit of Psychoradiology Chinese Academy of Medical Sciences Chengdu China"},{"name":"Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital of Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixuan","family":"Huang","sequence":"additional","affiliation":[{"name":"Huaxi MR Research Center (HMRRC), Department of Radiology West China Hospital of Sichuan University Chengdu China"},{"name":"Medical Imaging Technology Department, West China School of Medicine Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Guo","sequence":"additional","affiliation":[{"name":"Huaxi MR Research Center (HMRRC), Department of Radiology West China Hospital of Sichuan University Chengdu China"},{"name":"Research Unit of Psychoradiology Chinese Academy of Medical Sciences Chengdu China"},{"name":"Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital of Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyi","family":"Long","sequence":"additional","affiliation":[{"name":"Huaxi MR Research Center (HMRRC), Department of Radiology West China Hospital of Sichuan University Chengdu China"},{"name":"Research Unit of Psychoradiology Chinese Academy of Medical Sciences Chengdu China"},{"name":"Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital of Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lekai","family":"Luo","sequence":"additional","affiliation":[{"name":"Huaxi MR Research Center (HMRRC), Department of Radiology West China Hospital of Sichuan University Chengdu China"},{"name":"Research Unit of Psychoradiology Chinese Academy of Medical Sciences Chengdu China"},{"name":"Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital of Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanfang","family":"You","sequence":"additional","affiliation":[{"name":"Huaxi MR Research Center (HMRRC), Department of Radiology West China Hospital of Sichuan University Chengdu China"},{"name":"Research Unit of Psychoradiology Chinese Academy of Medical Sciences Chengdu China"},{"name":"Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital of Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Sweeney","sequence":"additional","affiliation":[{"name":"Huaxi MR Research Center (HMRRC), Department of Radiology West China Hospital of Sichuan University Chengdu China"},{"name":"Department of Psychiatry University of Cincinnati Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4737-5710","authenticated-orcid":false,"given":"Fei","family":"Li","sequence":"additional","affiliation":[{"name":"Huaxi MR Research Center (HMRRC), Department of Radiology West China Hospital of Sichuan University Chengdu China"},{"name":"Research Unit of Psychoradiology Chinese Academy of Medical Sciences Chengdu China"},{"name":"Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital of Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiyong","family":"Gong","sequence":"additional","affiliation":[{"name":"Huaxi MR Research Center (HMRRC), Department of Radiology West China Hospital of Sichuan University Chengdu China"},{"name":"Research Unit of Psychoradiology Chinese Academy of Medical Sciences Chengdu China"},{"name":"Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital of Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nurt.2007.05.011"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-183X.2008.00418.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2016.15111435"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2004.02.004"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2012.07.002"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2016.05.047"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2017.17050485"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2016.16020201"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcn.12563"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1503\/jpn.100082"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.05.095"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2018.05.008"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2016.07.022"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2018.00889"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1037\/0894-4105.20.2.178"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2013.13040574"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2019.00418"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpsy.2012.07.001"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2015.03.002"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.12988"},{"key":"e_1_2_10_22_1","first-page":"495","article-title":"Mild white matter changes in un\u2010medicated obsessive\u2010compulsive disorder patients and their unaffected siblings","volume":"9","author":"Fan S.","year":"2015","journal-title":"Frontiers in Neuroscience"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaac.2014.08.010"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1092852912000260"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.115.164020"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2017.22"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2009.11.003"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2015.07.035"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psc.2006.02.012"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-199804000-00020"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2011.06.004"},{"key":"e_1_2_10_32_1","series-title":"Neuroimaging Clinics of North America","first-page":"1","volume-title":"Psychoradiology","author":"Gong Q.","year":"2020"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2018.01.016"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1017\/neu.2015.57"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11682-016-9657-8"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/da.23008"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2009.11.3\/jhunsberger"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2009.01.003"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpsy.2011.07.001"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/da.21890"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(02)01492-3"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2010.11.001"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2014.03.006"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2007.08.018"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1155\/2007\/65704"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.1076"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5302-10.2011"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.12.053"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.442"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2018.08.021"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2007.09.005"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2010.09.016"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.1058"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajp.2012.07.004"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.janxdis.2018.11.001"},{"key":"e_1_2_10_56_1","article-title":"White matter microstructure and its relation to clinical features of obsessive\u2010compulsive disorder: Findings from the ENIGMA OCD Working Group","author":"Piras F.","year":"2019","journal-title":"bioRxiv"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2013.10.008"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2013.01.016"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00096"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2014.5"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.108.055046"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpsy.2011.04.001"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2014.00013"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(97)00443-5"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-5846(97)00163-2"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13587-014-0013-6"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2009.175"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2008.94"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2462061469"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2019.00186"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2013.04.003"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.02.024"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.212"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2010.06.011"},{"issue":"4","key":"e_1_2_10_75_1","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1093\/brain\/awn267","article-title":"The major symptom dimensions of obsessive\u2010compulsive disorder are mediated by partially distinct neural systems","volume":"132","author":"Heuvel O. A.","year":"2009","journal-title":"Brain"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2019.08.050"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-014-0215-2"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1159\/000323170"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1017\/neu.2016.45"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.30077"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2011.06.032"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1002\/da.22758"}],"container-title":["Brain and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.1975","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/brb3.1975","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.1975","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T21:01:25Z","timestamp":1693688485000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/brb3.1975"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,3]]},"references-count":81,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1002\/brb3.1975"],"URL":"https:\/\/doi.org\/10.1002\/brb3.1975","archive":["Portico"],"relation":{},"ISSN":["2162-3279","2162-3279"],"issn-type":[{"value":"2162-3279","type":"print"},{"value":"2162-3279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,3]]},"assertion":[{"value":"2020-08-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01975"}}