{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:45:18Z","timestamp":1791348318239,"version":"4.3.1"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,12,3]],"date-time":"2020-12-03T00:00:00Z","timestamp":1606953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We reviewed the psychotic symptoms of anti\u2010NMDA receptor encephalitis (NMDARE) to differentiate its presentation from those found in a primary psychiatric disorder. We hypothesized that the cycloid psychosis (CP) phenotype would be a frequent clinical presentation in the psychiatric phase of NMDARE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>A systematic literature review in PubMed of all case reports published on NMDARE was performed from database inception to March 2020. We included all cases where psychotic symptoms were reported and whose diagnoses were confirmed by the presence of anti\u2010NMDAR antibodies in the cerebrospinal fluid (CSF). An email including a short test (CP phenotype, Perris and Brockington's criteria) was sent to all case report authors asking them to describe the psychotic symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We identified 335 case reports fulfilling our criteria, and the authors of 200 replied. Our analyses were based exclusively on those answers and data extracted from the articles. Median patient age was 25\u00a0years (+\u201011.4), 81% were female, and 39% had an ovarian teratoma. A complete CP phenotype was identified in 175 patients (87%). These were acute psychotic episodes with a sudden onset and a fluctuating clinical pattern mostly characterized by confusion (97%), delusions (75%), hallucinations (69%), motility disturbances (87%), and mood oscillations (80%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The complete CP phenotype was frequently the expression of psychotic symptoms in NMDARE. We suggest that patients with a first psychotic episode who initially exhibit the CP phenotype should undergo CSF analysis to determine whether antibodies against neuronal cell surface or synaptic receptors are present to rule out a possible diagnosis of autoimmune encephalitis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.1980","type":"journal-article","created":{"date-parts":[[2020,12,3]],"date-time":"2020-12-03T10:38:18Z","timestamp":1606991898000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Cycloid psychosis as a psychiatric expression of anti\u2010NMDAR encephalitis. A systematic review of case reports accomplished with the authors' cooperation"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3130-5566","authenticated-orcid":false,"given":"Eloi","family":"Gin\u00e9 Serv\u00e9n","sequence":"first","affiliation":[{"name":"Psychiatry Department, Hospital de Matar\u00f3 Consorci Sanitari del Maresme Matar\u00f3 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ester","family":"Boix Quintana","sequence":"additional","affiliation":[{"name":"Psychiatry Department, Hospital de Matar\u00f3 Consorci Sanitari del Maresme Matar\u00f3 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Mart\u00ednez Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Psychiatry Department, Hospital de Matar\u00f3 Consorci Sanitari del Maresme Matar\u00f3 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolau","family":"Guanyabens Busc\u00e0","sequence":"additional","affiliation":[{"name":"Neurology Department, Hospital de Matar\u00f3 Consorci Sanitari del Maresme Matar\u00f3 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Desiree","family":"Muriana Batiste","sequence":"additional","affiliation":[{"name":"Neurology Department, Hospital de Matar\u00f3 Consorci Sanitari del Maresme Matar\u00f3 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar","family":"Guasp","sequence":"additional","affiliation":[{"name":"Neuroimmunology Program Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Hospital Cl\u00ednic Universitat de Barcelona Barcelona Spain"},{"name":"Neurology Department Hospital Cl\u00ednic Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Enfermedades Raras (CIBERER) Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Torres Rivas","sequence":"additional","affiliation":[{"name":"Neurology Department, Hospital de Matar\u00f3 Consorci Sanitari del Maresme Matar\u00f3 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Davi Loscos","sequence":"additional","affiliation":[{"name":"Psychiatry Department, Hospital de Matar\u00f3 Consorci Sanitari del Maresme Matar\u00f3 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Casado Ruiz","sequence":"additional","affiliation":[{"name":"Neurology Department, Hospital de Matar\u00f3 Consorci Sanitari del Maresme Matar\u00f3 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(19)30001-X"},{"key":"e_1_2_10_3_1","volume-title":"Bases neurofisiol\u00f3gicas de las psicosis at\u00edpicas. 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\u00e9tat mental et syndromes \u00e9pisodiques","author":"Magnan V.","year":"1895"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1986.tb10607.x"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1965.tb04996.x"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2535"},{"key":"e_1_2_10_20_1","volume-title":"Traite des degenerescences physiques, intellectuelles et morales de l\u2019espece humaine et des causes qui produisent ces varietes maladives par le Docteur BA Morel","author":"Morel B.\u2010A.","year":"1857"},{"key":"e_1_2_10_21_1","first-page":"1","article-title":"A study of cycloid psychoses","volume":"253","author":"Perris C.","year":"1974","journal-title":"Acta Psychiatrica Scandinavica"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700055586"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181fc2a06"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.neuropsych.18010005"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/15622975.2018.1555376"},{"key":"e_1_2_10_26_1","first-page":"144\u2010","article-title":"1933 [classical article]","volume":"151","author":"The acute schizoaffective psychoses","year":"1994","journal-title":"Acta Psychiatrica Scandinavica"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12941"}],"container-title":["Brain and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.1980","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/brb3.1980","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.1980","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T17:02:37Z","timestamp":1693674157000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/brb3.1980"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,3]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1002\/brb3.1980"],"URL":"https:\/\/doi.org\/10.1002\/brb3.1980","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/BRB3.1980\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.1980\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.1980\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.1980\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.1980\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.1980\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.1980\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.1980\/v2\/decision1","asserted-by":"object"}]},"ISSN":["2162-3279","2162-3279"],"issn-type":[{"value":"2162-3279","type":"print"},{"value":"2162-3279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,3]]},"assertion":[{"value":"2020-06-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01980"}}