{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T02:21:43Z","timestamp":1774578103740,"version":"3.50.1"},"reference-count":52,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,12,9]],"date-time":"2020-12-09T00:00:00Z","timestamp":1607472000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010251","name":"Youth Science Foundation of Jiangxi Province","doi-asserted-by":"publisher","award":["20151BAB215016"],"award-info":[{"award-number":["20151BAB215016"]}],"id":[{"id":"10.13039\/501100010251","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010251","name":"Youth Science Foundation of Jiangxi Province","doi-asserted-by":"publisher","award":["20161BAB215198"],"award-info":[{"award-number":["20161BAB215198"]}],"id":[{"id":"10.13039\/501100010251","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The purpose of this study is to explore the underlying functional network brain activity changes of patients in middle\u2010aged with retinitis pigmentosa (RP) and the relationships with clinical features such as depression scale and visual functioning using voxel\u2010wise degree centrality (DC) method.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We included 16 patients with RP (11 men, 5 women) and 16 healthy controls (HCs; 11 men, 5 women). Participants were matched in terms of age, weight, gender and handedness (age and weight between the two groups were compared using independent sample\n                      <jats:italic>t<\/jats:italic>\n                      \u2010tests, gender and handedness were compared using chi\u2010square test). We use the voxel\u2010wise DC method to assess spontaneous brain activity. Receiver operating characteristic (ROC) curve analysis was performed to distinguish between RP patients and HCs. Correlation analysis was used to examine the relationships between mean DC values in various brain regions and clinical features (such as depression scale and visual functioning) in RP patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared with HCs, the DC values of patients with RP were reduced in the right medial frontal gyrus, bilateral cuneus, bilateral precuneus, and bilateral superior frontal gyrus, and increased in the right cerebellum posterior lobe, left inferior temporal gyrus, and right fusiform gyrus. The mean DC values in the bilateral cuneus negatively correlated with the depression scale, and those in the bilateral precuneus positively correlated with the Visual Functioning Questionnaire\u201025.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Middle\u2010aged patients with RP exhibit abnormal brain network activity in various brain regions, and this may underlie the pathological mechanism of RP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.1983","type":"journal-article","created":{"date-parts":[[2020,12,10]],"date-time":"2020-12-10T04:34:13Z","timestamp":1607574853000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Altered brain network centrality in middle\u2010aged patients with retinitis pigmentosa: A resting\u2010state functional magnetic resonance imaging study"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9742-1674","authenticated-orcid":false,"given":"Qi","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Jiangxi Province Ocular Disease Clinical Research Center The First Affiliated Hospital of Nanchang University  Nanchang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei\u2010Ying","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Jiangxi Province Ocular Disease Clinical Research Center The First Affiliated Hospital of Nanchang University  Nanchang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong\u2010Qiang","family":"Shu","sequence":"additional","affiliation":[{"name":"Department of Radiology The First Affiliated Hospital of Nanchang University  Nanchang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei\u2010Wen","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Jiangxi Province Ocular Disease Clinical Research Center The First Affiliated Hospital of Nanchang University  Nanchang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Jiangxi Province Ocular Disease Clinical Research Center The First Affiliated Hospital of Nanchang University  Nanchang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen\u2010Qing","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Jiangxi Province Ocular Disease Clinical Research Center The First Affiliated Hospital of Nanchang University  Nanchang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"You\u2010Lan","family":"Min","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Jiangxi Province Ocular Disease Clinical Research Center The First Affiliated Hospital of Nanchang University  Nanchang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Biao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Jiangxi Province Ocular Disease Clinical Research Center The First Affiliated Hospital of Nanchang University  Nanchang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Jiangxi Province Ocular Disease Clinical Research Center The First Affiliated Hospital of Nanchang University  Nanchang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1571-2433","authenticated-orcid":false,"given":"Yi","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Jiangxi Province Ocular Disease Clinical Research Center The First Affiliated Hospital of Nanchang University  Nanchang China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,12,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-017-1404-4"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0141389"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl004"},{"issue":"13","key":"e_1_2_11_5_1","first-page":"13","article-title":"DPARSF: A MATLAB toolbox for \"pipeline\" data analysis of resting\u2010state fMRI","volume":"4","author":"Chao\u2010Gan Y.","year":"2010","journal-title":"Frontiers in Systems Neuroscience"},{"key":"e_1_2_11_6_1","volume-title":"Cuneus[M]. Previous studies demonstrated that the cuneus","author":"Cohen R. 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X.","year":"2018","journal-title":"International Journal of Ophthalmology"},{"key":"e_1_2_11_17_1","first-page":"3075","article-title":"Disturbedspontaneous brain\u2010activity pattern in patients with optic neuritis using amplitude of low\u2010frequency fluctuation: A functional magnetic resonance imaging study","volume":"11","author":"Huang X.","year":"2015","journal-title":"Neuropsychiatric Disease and Treatment"},{"key":"e_1_2_11_18_1","first-page":"1","article-title":"Disturbed spontaneous brain activity pattern in patients with primary angle closure glaucoma using amplitude of low\u2010frequency fluctuation: An fMRI study","volume":"11","author":"Huang X.","year":"2015","journal-title":"Neuropsychiatric Disease and Treatment"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2005.10.012"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1162\/089892903321662949"},{"key":"e_1_2_11_21_1","first-page":"282","volume-title":"An Introduction to Brain and Behavior","author":"Kolb B.","year":"2014"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(82)90085-3"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145714000947"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/8135671"},{"key":"e_1_2_11_25_1","first-page":"86","article-title":"Prevalence of increases in functional connectivity in visual, somatosensory and language areas in congenital blindness","volume":"9","author":"Lizette H.","year":"2015","journal-title":"Frontiers in Neuroanatomy"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.05.008"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-11-03942.2001"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1999.0451"},{"key":"e_1_2_11_29_1","unstructured":"O'Neal T. B. &Luther E. E.(2018).Retinitis Pigmentosa. [Updated 2018 Aug 14]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing. Retrieved from:https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK519518\/"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.213"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.1999.00518.x"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2001.02090.x"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.98.2.676"},{"key":"e_1_2_11_34_1","volume-title":"The Tell Tale Brain","author":"Ramachandran V. S.","year":"2011"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S92968"},{"issue":"1","key":"e_1_2_11_36_1","first-page":"19","article-title":"The application of functional magnetic resonance imaging in ophthalmology","volume":"4","author":"Shi W. 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