{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T13:56:37Z","timestamp":1775483797659,"version":"3.50.1"},"reference-count":47,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T00:00:00Z","timestamp":1607040000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The aim of the study was to investigate factors which may predispose patients to early neurological deterioration (END) and explore peripheral biomarkers for the prediction of END in cardiogenic cerebral embolism (CCE) patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients diagnosed with CCE within 24\u00a0hr of onset between January 2017 and January 2019 were included in this study. END was defined as an increase of \u22652 on the National Institutes of Health Stroke Scale (NIHSS) or the emergence of new neurological symptoms within 3\u00a0days of admission. Binary logistic regression was used to investigate the factors associated with END. Receiver operating characteristic (ROC) curves were then generated to determine the predictive value of the potential biomarkers and the optimal cutoff values.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 129 (male, 55.81%; mean age 71.85\u00a0\u00b1\u00a011.99\u00a0years) CCE patients, 55 patients with END were identified. Hemorrhage transformation (HT), coronary heart disease (CHD), diastolic blood pressure, cystatin C levels, NIHSS score, and platelet\u2010to\u2010lymphocyte ratio (PLR) at admission were independently associated with END. A peripheral cystatin C level\u00a0\u2265\u00a01.41\u00a0mg\/L and a PLR\u00a0\u2265\u00a0132.97 were predictive factors for END in CCE patients. The lymphocyte\u2010to\u2010monocyte ratio (LMR) was negatively independently associated with HT, and LMR\u00a0&lt;\u00a02.31 may predict the occurrence of HT in patients with CCE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Of the potential predisposing factors considered, increased cystatin C and PLR were associated with END within 3\u00a0days of CCE, and a decreased LMR may have predictive value for HT in CCE patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.1985","type":"journal-article","created":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T23:23:13Z","timestamp":1607124193000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Early neurological deterioration in cardiogenic cerebral embolism due to nonvalvular atrial fibrillation: Predisposing factors and clinical 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