{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:02:04Z","timestamp":1772118124593,"version":"3.50.1"},"reference-count":86,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,12,8]],"date-time":"2020-12-08T00:00:00Z","timestamp":1607385600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Data on differences in brain features between monozygotic (MZ) twins with and without schizophrenia are scarce.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We compared brain features of female MZ twins with and without first\u2010episode schizophrenia and healthy controls (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a020 each). Voxel\u2010based morphometry and tract\u2010based spatial statistics were used to analyze differences in brain structure. Whole\u2010brain effective connectivity (EC) and functional connectivity (FC) networks were constructed using resting\u2010state functional magnetic resonance imaging (rs\u2010fMRI) data.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Female twins with schizophrenia exhibited abnormal gray matter volume (GMV) in the basal ganglia and prefrontal and parietal cortices, impairments in the arcuate fasciculus, and significant disruptions (primarily decreases) in nine EC networks. They exhibited rs\u2010EC alterations involving the limbic areas and subcortex. Combined rs\u2010EC and rs\u2010FC data distinguished twins with first\u2010episode schizophrenia with high accuracy. Combined consideration of structural and functional features enabled the distinction of female MZ twins with schizophrenia from those without schizophrenia and healthy controls with 100% accuracy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Female MZ twins with schizophrenia exhibited increased GMV, white matter impairment, and disruptions in EC and FC networks. The combination of rs\u2010EC\u00a0+\u00a0rs\u2010FC data could distinguish female twins with schizophrenia from twins without schizophrenia and healthy controls with 97.4% accuracy, and the addition of structural brain features yielded a 100% accuracy rate. These findings may provide pivotal insight for further study of the mechanisms underlying schizophrenia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.1992","type":"journal-article","created":{"date-parts":[[2020,12,9]],"date-time":"2020-12-09T22:08:50Z","timestamp":1607551730000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Brain features of nearly drug\u2010na\u00efve female monozygotic twins with first\u2010episode schizophrenia and the classification accuracy of brain feature patterns: A pilot study"],"prefix":"10.1002","volume":"11","author":[{"given":"Tao","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Psychiatry Dongying Shengli Hospital  Dongying China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Shanghai Qingpu District Mental Health Center  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