{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T02:17:40Z","timestamp":1783477060832,"version":"3.55.0"},"reference-count":61,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,2,27]],"date-time":"2021-02-27T00:00:00Z","timestamp":1614384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    A meta\u2010analysis was performed to examine therapeutic effects of Silexan on somatic symptoms, including insomnia\/fatigue, and physical health in patients with anxiety disorders. Five randomized, placebo\u2010controlled trials were included in this analysis: The efficacy of Silexan (80\u00a0mg\/day) was investigated in patients with subthreshold anxiety disorders (three trials) and in patients with generalized anxiety disorder (two trials). Silexan was superior to placebo in terms of the mean change from baseline in the Hamilton Anxiety Rating Scale (HAMA) subscore somatic anxiety at week 10 with a standardized mean difference of \u22120.31 [95% Cl: \u22120.52 to \u22120.10,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.004]. Treatment effects of silexan on somatic anxiety were independent of gender and age. Statistically significant differences were also shown for single HAMA items somatic muscular, cardiovascular, respiratory, and genitourinary symptoms, indicating clinical relevance with small to medium effects of Silexan. Similar clinically meaningful effects of Silexan on SF\u201036 physical health, including reduced bodily pain and improved general health, and on insomnia complaints and fatigue, were demonstrated. In this meta\u2010analysis including all placebo\u2010controlled clinical trials in patients with anxiety disorders to date, statistically significant and clinically meaningful advantages of Silexan over placebo treatment were found in improving somatic symptoms and physical health.\n                  <\/jats:p>","DOI":"10.1002\/brb3.1997","type":"journal-article","created":{"date-parts":[[2021,2,27]],"date-time":"2021-02-27T07:54:32Z","timestamp":1614412472000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Therapeutic effects of Silexan on somatic symptoms and physical health in patients with anxiety disorders: A meta\u2010analysis"],"prefix":"10.1002","volume":"11","author":[{"given":"Roland","family":"von K\u00e4nel","sequence":"first","affiliation":[{"name":"Department of Consultation\u2010Liaison\u2010Psychiatry and Psychosomatic Medicine University Hospital Zurich University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siegfried","family":"Kasper","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Bondolfi","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University Medical Centre University of Geneva  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edith","family":"Holsboer\u2010Trachsler","sequence":"additional","affiliation":[{"name":"Gesundheitszentrum St. Johann University of Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josef","family":"H\u00e4ttenschwiler","sequence":"additional","affiliation":[{"name":"Centre for Anxiety and Depression Treatment Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Hatzinger","sequence":"additional","affiliation":[{"name":"Psychiatric Services Solothurn and University of Basel  Solothurn Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Imboden","sequence":"additional","affiliation":[{"name":"Private Clinic Wyss  M\u00fcnchenbuchsee Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Heitlinger","sequence":"additional","affiliation":[{"name":"H+O communications Ltd.  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erich","family":"Seifritz","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Psychotherapy and Psychosomatics Psychiatric Hospital University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,27]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/da.20600"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ijnp\/pyu063"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145710001434"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2015.17.3\/bbandelow"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1497.2001.016004266.x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.janxdis.2010.03.015"},{"key":"e_1_2_11_9_1","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1002\/9780470743386","volume-title":"Introduction to Meta\u2010Analysis","author":"Borenstein M.","year":"2009"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-011-1148-2"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291713002997"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-016-0739-5"},{"key":"e_1_2_11_13_1","first-page":"82","volume-title":"Statistical power analysis for the behavioral sciences","author":"Cohen J.","year":"1988"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.4135\/9781483348858.n11"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.janxdis.2015.12.001"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.151.6.930"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.328.7445.939"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0106907"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/0706743716640757"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-7094(11)70029-0"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0150664"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000118565"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2007.4"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.4088\/PCC.v02n0204"},{"issue":"11","key":"e_1_2_11_25_1","first-page":"13","article-title":"Threshold and subthreshold Generalized Anxiety Disorder (GAD) and suicide ideation","volume":"27","author":"Gilmour H.","year":"2016","journal-title":"Health Reports"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v60n0702"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-244X-14-128"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2044-8341.1959.tb00467.x"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d5928"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/da.20257"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2017.01.021"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1592\/phco.27.11.1571"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10354-015-0360-y"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2015.07.024"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145714000017"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/YIC.0b013e32833b3242"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/YIC.0000000000000176"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2015.12.002"},{"issue":"3","key":"e_1_2_11_39_1","first-page":"168","article-title":"Lifetime prevalence and age\u2010of\u2010onset distributions of mental disorders in the World Health Organization's World Mental Health Survey Initiative","volume":"6","author":"Kessler R. 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