{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T12:51:19Z","timestamp":1791723079363,"version":"4.3.4"},"reference-count":43,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T00:00:00Z","timestamp":1610668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2010\/15604\u20100"],"award-info":[{"award-number":["2010\/15604\u20100"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2010\/15786\u20101"],"award-info":[{"award-number":["2010\/15786\u20101"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2010\/18374\u20106"],"award-info":[{"award-number":["2010\/18374\u20106"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2011\/19185\u20105"],"award-info":[{"award-number":["2011\/19185\u20105"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Neuroimaging studies have shown callosal abnormalities among maltreated subjects, but little is known about the functional and neurobiological correlates of these supposed developmental alterations. The aim of this study was to investigate childhood maltreatment (CM), neurocognitive functioning, cortisol levels, and corpus callosum (CC) integrity among adolescents.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>One hundred and seven subjects underwent magnetic resonance imaging (MRI) with voxel\u2010based diffusion\u2010tensor imaging (DTI) and the Crossed Finger Localization Test (CFLT). Psychopathology was investigated with the Schedule for Affective Disorders and Schizophrenia (K\u2010SADS\u2010PL); CM was detailed by the Childhood Trauma Questionnaire (CTQ), and salivary cortisol levels were measured by immunoassay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Higher levels of CM were associated with current lower CFLT scores, mainly in the CROSSED condition, involving interhemispheric communication of sensorimotor information (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.05) and with reduced fractional anisotropy (FA) in the\n                      <jats:italic>splenium<\/jats:italic>\n                      of the CC (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.01). Deficits in the CFLT were also associated with higher cortisol levels (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The association among CM, neuropsychological abnormalities, callosal microstructure alterations, and cortisol levels suggests an altered pattern of brain interhemispheric connectivity among maltreated adolescents. Further studies are needed to investigate the extent to which these sensorimotor deficits and abnormal cortisol levels may be possible mediators of negative neurodevelopmental trajectories and adult psychopathology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.2009","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T22:48:41Z","timestamp":1610750921000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Callosal abnormalities, altered cortisol levels, and neurocognitive deficits associated with early maltreatment among adolescents: A voxel\u2010based diffusion\u2010tensor imaging study"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2288-9838","authenticated-orcid":false,"given":"Paulo Jannuzzi","family":"Cunha","sequence":"first","affiliation":[{"name":"Laboratory of Psychiatric Neuroimaging (LIM\u201021) Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP Faculdade de Medicina Universidade de Sao Paulo Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio L.S.","family":"Duran","sequence":"additional","affiliation":[{"name":"Laboratory of Psychiatric Neuroimaging (LIM\u201021) Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP Faculdade de Medicina Universidade de Sao Paulo Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula Approbato","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Departamento e Instituto de Psiquiatria Hospital das Clinicas HCFMUSP Faculdade de Medicina Universidade de Sao Paulo Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0798-3233","authenticated-orcid":false,"given":"Tiffany M.","family":"Chaim\u2010Avancini","sequence":"additional","affiliation":[{"name":"Laboratory of Psychiatric Neuroimaging (LIM\u201021) Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP Faculdade de Medicina Universidade de Sao Paulo Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Luiza V.","family":"Milioni","sequence":"additional","affiliation":[{"name":"Laboratory of Psychiatric Neuroimaging (LIM\u201021) Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP Faculdade de Medicina Universidade de Sao Paulo Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariella","family":"Ometto","sequence":"additional","affiliation":[{"name":"Laboratory of Psychiatric Neuroimaging (LIM\u201021) Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP Faculdade de Medicina Universidade de Sao Paulo Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Squarzoni","sequence":"additional","affiliation":[{"name":"Laboratory of Psychiatric Neuroimaging (LIM\u201021) Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP Faculdade de Medicina Universidade de Sao Paulo Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro P.","family":"Santos","sequence":"additional","affiliation":[{"name":"Laboratory of Psychiatric Neuroimaging (LIM\u201021) Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP Faculdade de Medicina Universidade de Sao Paulo Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila C.","family":"Caetano","sequence":"additional","affiliation":[{"name":"Departamento de Psiquiatria Universidade Federal de S\u00e3o Paulo (UNIFESP) S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geraldo F.","family":"Busatto","sequence":"additional","affiliation":[{"name":"Laboratory of Psychiatric Neuroimaging (LIM\u201021) Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP Faculdade de Medicina Universidade de Sao Paulo Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Scivoletto","sequence":"additional","affiliation":[{"name":"Departamento e Instituto de Psiquiatria Hospital das Clinicas HCFMUSP Faculdade de Medicina Universidade de Sao Paulo Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,15]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"Andersson J. L. R. Jenkinson M. &Smith S.(June 2007).Non\u2010linear registration aka spatial normalization. FMRIB Analysis Group of the University of Oxford. FMRIB technical report TR07JA2. Retrieved fromwww.fmrib.ox.ac.uk\/analysis\/techrep"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.151.8.1132"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0145-2134(02)00541-0"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-017-0032-3"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2010.06.003"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1017\/S095457941400008X"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0954579401003078"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0954579415000942"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2016.02.068"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291715000239"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3932(85)90004-1"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1308.009"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0034-89102006000200010"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2018.00007"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/2045-5380-3-21"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2012.133"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2007.08.006"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpsc.2018.08.006"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-199707000-00021"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jadohealth.2019.11.308"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1119"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.9758\/cpn.2018.16.1.46"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2020.07.004"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5122-09.2010"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2639"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11682-017-9703-1"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-019-0472-y"},{"key":"e_1_2_10_29_1","volume-title":"Introduction to diffusion tensor imaging","author":"Mori S.","year":"2007"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-044451741-8\/50003-2"},{"issue":"1","key":"e_1_2_10_31_1","doi-asserted-by":"crossref","first-page":"e01485","DOI":"10.1002\/brb3.1485","article-title":"Childhood maltreatment experiences are associated with altered diffusion in occipito\u2010temporal white matter pathways","volume":"10","author":"Olson E. A.","year":"2019","journal-title":"Brain and Behavior"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00787-015-0744-y"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S1549"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01537962"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23423"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1109\/42.796284"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617707071123"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-9452(13)80138-4"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11682-007-9015-y"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1200041109"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-8624.2009.01263.x"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpp.12507"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23916"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.32.6.645"}],"container-title":["Brain and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.2009","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/brb3.2009","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.2009","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T17:20:52Z","timestamp":1697563252000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/brb3.2009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,15]]},"references-count":43,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["10.1002\/brb3.2009"],"URL":"https:\/\/doi.org\/10.1002\/brb3.2009","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/BRB3.2009\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.2009\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.2009\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.2009\/v1\/decision1","asserted-by":"object"}]},"ISSN":["2162-3279","2162-3279"],"issn-type":[{"value":"2162-3279","type":"print"},{"value":"2162-3279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,15]]},"assertion":[{"value":"2019-12-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e02009"}}