{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:56:04Z","timestamp":1791287764404,"version":"4.3.0"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,1,16]],"date-time":"2021-01-16T00:00:00Z","timestamp":1610755200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim of this study is to explore mania as a network of its symptoms, inspired by the network approach to mental disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Network structures of both cross\u2010sectional and temporal effects were measured at three time points (admission, middle of hospital stay, and discharge) in a sample of 100 involuntarily committed patients diagnosed with bipolar I disorder with severe manic features and hospitalized in a specialized psychiatric ward.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Elevated mood is the most interconnected symptom in the network on admission, while aggressive behavior and irritability are highly predictive of each other, as well as language\u2010thought disorder and \u201ccontent\u201d (the presence of abnormal ideas or delusions). Elevated mood is influenced by many symptoms in the temporal network.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The investigation of manic symptoms with network analysis allows for identifying important symptoms that are better connected to other symptoms at a given moment and over time. The connectivity of the manic symptoms evolves over time. Central symptoms could be considered as targets for clinical intervention when treating severe mania.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.2010","type":"journal-article","created":{"date-parts":[[2021,1,16]],"date-time":"2021-01-16T07:40:37Z","timestamp":1610782837000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["A network structure of manic symptoms"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4038-3363","authenticated-orcid":false,"given":"Giovanni","family":"Briganti","sequence":"first","affiliation":[{"name":"Unit of Epidemiology, Biostatistics, and Clinical Research Universit\u00e9 libre de Bruxelles Brussels Belgium"},{"name":"Laboratoire de Psychologie M\u00e9dicale et Addictologie Universit\u00e9 libre de Bruxelles Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Kornreich","sequence":"additional","affiliation":[{"name":"Laboratoire de Psychologie M\u00e9dicale et Addictologie Universit\u00e9 libre de Bruxelles Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Linkowski","sequence":"additional","affiliation":[{"name":"Unit of Epidemiology, Biostatistics, and Clinical Research Universit\u00e9 libre de Bruxelles Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,16]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000495045"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/wps.20375"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-clinpsy-050212-185608"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2018.12.080"},{"key":"e_1_2_11_7_1","doi-asserted-by":"crossref","first-page":"e1810","DOI":"10.1002\/mpr.1810","article-title":"Exploring network structure and central items of the Narcissistic Personality Inventory","volume":"29","author":"Briganti G.","year":"2019","journal-title":"International Journal of Methods in Psychiatric Research"},{"issue":"1","key":"e_1_2_11_8_1","first-page":"30","article-title":"Une nouvelle approche ontologique et statistique des construits et troubles mentaux: Introduction \u00e0 la psychiatrie des \u201cnetworks\u201d","volume":"25","author":"Briganti G.","year":"2020","journal-title":"Neurone"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S12663"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2019.02.017"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.31234\/osf.io\/8ha93"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3758\/s13428-017-0862-1"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v048.i04"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2015.09.005"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2014.10.010"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.2307\/1912791"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brat.2014.12.002"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291717001258"},{"key":"e_1_2_11_19_1","volume-title":"mgm: Structure estimation for time\u2010varying mixed graphical models in high\u2010dimensional data","author":"Haslbeck J. 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