{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:02:04Z","timestamp":1772118124868,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,1,7]],"date-time":"2021-01-07T00:00:00Z","timestamp":1609977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010590","name":"Tianjin Municipal Bureau of Public Health","doi-asserted-by":"publisher","award":["14KG105"],"award-info":[{"award-number":["14KG105"]}],"id":[{"id":"10.13039\/501100010590","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Olfactory dysfunction is a common and early sign of many neurodegenerative disorders, but little is known about olfactory dysfunction in Wilson\u2019s disease (WD). We aimed to evaluate olfactory function in patients with WD and identify selective WD screening odors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We measured olfactory identification ability in 25 patients with WD and 25 healthy controls using the University of Pennsylvania Smell Identification Test (UPSIT). Patients with WD were evaluated using the Global Assessment Scale for WD (GAS). Cognitive function was measured using the Mini\u2013Mental State Examination.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients with WD were worse at identifying smells in the simplified Chinese version of the UPSIT compared with healthy controls (\n                      <jats:italic>t<\/jats:italic>\n                      \u00a0=\u00a02.198,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.033), but there was no difference in olfactory dysfunction severity between the groups (\n                      <jats:italic>V<\/jats:italic>\n                      \u00a0=\u00a0136,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.094). UPSIT scores negatively correlated with the GAS neurological scores in patients with WD (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a0\u22120.571,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.003). Using logistic regression with least absolute shrinkage and selection operator analysis, two models were screened. Receiver\u2010operating characteristic (ROC) curve analysis revealed that, to discriminate WD patients from healthy controls, the area under the ROC curve (AUC) for a combination of seven odors (motor oil, onion, licorice, strawberry, tire, jasmine, and natural gas) was 0.926, while the AUC for three odors (onion, licorice, and jasmine) was 0.852.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients with WD may have stable, selective olfactory impairments. This selective pattern may be a useful tool for disease diagnosis and prediction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.2022","type":"journal-article","created":{"date-parts":[[2021,1,12]],"date-time":"2021-01-12T20:07:30Z","timestamp":1610482050000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Olfactory impairment in Wilson\u2019s disease"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1760-2046","authenticated-orcid":false,"given":"Lei","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Neurology Tianjin Huan Hu Hospital Tianjin Key Laboratory of Cerebrovascular and Neurodegenerative Diseases Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology Tianjin Huan Hu Hospital Tianjin Key Laboratory of Cerebrovascular and Neurodegenerative Diseases Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard L.","family":"Doty","sequence":"additional","affiliation":[{"name":"Smell and Taste Center Perelman School of Medicine University of Pennsylvania Philadelphia PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanshan","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Gerontology The No. 2 Hospital of Baoding Baoding China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junxiu","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurology Hebei Petro China Central Hospital Langfang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Neurology Tianjin Medical University General Hospital Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyan","family":"Yan","sequence":"additional","affiliation":[{"name":"Peking University Clinical Research Institute Peking University First Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,1,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22231"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70190-5"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0b013e3280102302"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7NP00016B"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22155"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-006-0284-y"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-63625-6.00010-0"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-018-5216-9"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30123-0"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-63855-7.00020-4"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.41.5_Suppl_2.77"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198402000-00004"},{"issue":"10","key":"e_1_2_10_14_1","first-page":"1339","article-title":"Olfactory dysfunction in hereditary ataxia and basal ganglia disorders","volume":"14","author":"Fernandez\u2010Ruiz J.","year":"2003","journal-title":"NeuroReport"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1017\/9781139192446"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)93027-X"},{"key":"e_1_2_10_17_1","first-page":"431","article-title":"The applicability of the University of Pennsylvania Smell Identification Test and Cross\u2010Cultural Smell Identification Test in Taiwan","volume":"37","author":"Jiang R. 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