{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T17:14:41Z","timestamp":1791047681508,"version":"4.1.0"},"reference-count":54,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,1,27]],"date-time":"2021-01-27T00:00:00Z","timestamp":1611705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771398"],"award-info":[{"award-number":["81771398"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the effectiveness of alpha activity neurofeedback training over the parietal lobe in GAD patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Twenty\u2010six female patients who had been diagnosed as GAD according to the Diagnostic and Statistical Manual of Mental Disorders (5th edition, DSM\u2010V) criteria were included in this study. Patients were randomized into two groups: the left parietal lobe training group (LPL group,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a013) and the right parietal lobe training group (RPL group,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a013), and then received ten 40\u2010minute alpha training sessions in the relevant area. Evaluations included severity of anxiety (by State\u2010Trait Anxiety Inventory, STAI) and depression (by Beck Depression Inventory, BDI\u2010II) after the fifth training session and the last training session.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The scores of STAI\u2010S decreased significantly two weeks after the fifth training session in both groups (LPL group: from 47.15\u00a0\u00b1\u00a010.65 to 38.69\u00a0\u00b1\u00a08.78,\n                      <jats:italic>p<\/jats:italic>\n                      &lt;.05; RPL group: from 44.92\u00a0\u00b1\u00a012.37 to 37.31\u00a0\u00b1\u00a06.41,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.05) and decreased further at the four weeks\u2019 time point after the last training session (LPL group: 35.15\u00a0\u00b1\u00a09.24; RPL group: 29.85\u00a0\u00b1\u00a06.18). Compared with baseline, the scores of STAI\u2010T, BDI\u2010II and ISI decrease at two weeks, no significant difference found between LPL group and RPL group. The scores of STAI\u2010T, BDI\u2010II and ISI decreased at four weeks when compared with two weeks, and no significant difference found between LPL group and RPL group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Neurofeedback training of alpha activity over the parietal lobe is effective in GAD patients, especially the anxiety trait and depressive symptoms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.2024","type":"journal-article","created":{"date-parts":[[2021,1,27]],"date-time":"2021-01-27T12:54:51Z","timestamp":1611752091000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Neurofeedback training improves anxiety trait and depressive symptom in GAD"],"prefix":"10.1002","volume":"11","author":[{"given":"Yue","family":"Hou","sequence":"first","affiliation":[{"name":"Department of Neurology Xuanwu Hospital Capital Medical University Beijing China"},{"name":"The Beijing Key Laboratory of Neuromodulation Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuqin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology Xuanwu Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology Xuanwu Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoyang","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Neurology Xuanwu Hospital Capital Medical University Beijing China"},{"name":"The Beijing Key Laboratory of Neuromodulation Beijing 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