{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T22:23:19Z","timestamp":1783981399660,"version":"3.55.0"},"reference-count":116,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,1,9]],"date-time":"2021-01-09T00:00:00Z","timestamp":1610150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>At the end of December 2019, a novel respiratory infection, initially reported in China, known as COVID\u201019 initially reported in China, and later known as COVID\u201019, led to a global pandemic. Despite many studies reporting respiratory infections as the primary manifestations of this illness, an increasing number of investigations have focused on the central nervous system (CNS) manifestations in COVID\u201019. In this study, we aimed to evaluate the CNS presentations in COVID\u201019 patients in an attempt to identify the common CNS features and provide a better overview to tackle this new pandemic.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this systematic review and meta\u2010analysis, we searched PubMed, Web of Science, Ovid, EMBASE, Scopus, and Google Scholar. Included studies were publications that reported the CNS features between 1 January 2020 and 20 April 2020. The data of selected studies were screened and extracted independently by four reviewers. Extracted data analyzed by using STATA statistical software. The study protocol registered with PROSPERO (CRD42020184456).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 2,353 retrieved studies, we selected 64 studies with 11,687 patients after screening. Most of the studies were conducted in China (58 studies). The most common CNS symptom of COVID\u201019 was headache (8.69%, 95%CI: 6.76%\u201310.82%), dizziness (5.94%, 95%CI: 3.66%\u20138.22%), and impaired consciousness (1.90%, 95%CI: 1.0%\u20132.79%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The growing number of studies has reported COVID\u201019, CNS presentations as remarkable manifestations that happen. Hence, understanding the CNS characteristics of COVID\u201019 can help us for better diagnosis and ultimately prevention of worse outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.2025","type":"journal-article","created":{"date-parts":[[2021,1,14]],"date-time":"2021-01-14T14:56:11Z","timestamp":1610636171000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Central nervous system manifestations in COVID\u201019 patients: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"11","author":[{"given":"Shahrzad","family":"Nazari","sequence":"first","affiliation":[{"name":"Department of Neuroscience and Addiction Studies School of Advanced Technologies in Medicine Tehran University of Medical Sciences Tehran 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