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It is well established however that electrophysiological signals comprise a broadband scale\u2010free (or fractal) component generated by mechanisms different from those producing oscillatory neural activity. Despite this known feature, it has not yet been investigated if spectral abnormalities found in SZ could be attributed to scale\u2010free or oscillatory brain function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this study, we analyzed resting\u2010state EEG recordings of 14 SZ patients and 14 healthy controls. Scale\u2010free and oscillatory components of the power spectral density (PSD) were separated, and band\u2010limited power (BLP) of the original (mixed) PSD, as well as its fractal and oscillatory components, was estimated in five frequency bands. The scaling property of the fractal component was characterized by its spectral exponent in two distinct frequency ranges (1\u201313 and 13\u201330\u00a0Hz).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Analysis of the mixed PSD revealed a decrease of BLP in the delta band in SZ over the central regions; however, this difference could be attributed almost exclusively to a shift of power toward higher frequencies in the fractal component. Broadband neural activity expressed a true bimodal nature in all except frontal regions. Furthermore, both low\u2010 and high\u2010range spectral exponents exhibited a characteristic topology over the cortex in both groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our results imply strong functional significance of scale\u2010free neural activity in SZ and suggest that abnormalities in PSD may emerge from alterations of the fractal and not only the oscillatory components of neural activity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.2047","type":"journal-article","created":{"date-parts":[[2021,2,6]],"date-time":"2021-02-06T11:39:45Z","timestamp":1612611585000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Separating scale\u2010free and oscillatory components of neural activity in 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