{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T10:01:36Z","timestamp":1787738496619,"version":"build-2784847793"},"reference-count":14,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T00:00:00Z","timestamp":1611878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Previous studies reported variable sensitivity and specificity of the Phalen test. We investigated whether a timed Phalen\u2019s test (TPT) could predict abnormal nerve conduction studies (NCS) results in carpal tunnel syndrome (CTS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with CTS were consecutively recruited. A neurologist confirmed the clinical diagnosis of CTS and recorded the TPT before NCS were performed. Another neurologist, blinded to the TPT, graded the severity of NCS. The TPT sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were calculated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 403 patients with 706 hands were recruited and diagnosed with CTS; 465 hands had positive TPT, and 611 hands showed abnormal NCS results. A positive TPT at\u00a0\u2264\u00a010\u00a0s had a specificity of 96.8% and a PPV of 96.6% in predicting abnormal NCS. The sensitivity and NPV of TPT were insignificant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>A positive TPT at\u00a0\u2264\u00a010\u00a0s can be useful in predicting NCS abnormalities in patients with CTS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.2056","type":"journal-article","created":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T04:06:37Z","timestamp":1611893197000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["A timed Phalen\u2019s test predicts abnormal electrophysiology in carpal tunnel syndrome"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5177-8283","authenticated-orcid":false,"given":"Mohammed H.","family":"Alanazy","sequence":"first","affiliation":[{"name":"Department of Internal Medicine College of Medicine King Saud University Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hana","family":"Albulaihe","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine College of Medicine King Saud University Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziad","family":"Alhumayyd","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine College of Medicine King Saud University Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anas M.","family":"Albarrak","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine College of Medicine Prince Sattam Bin Abdulaziz University Alkharj Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5442-6734","authenticated-orcid":false,"given":"Ahmad R.","family":"Abuzinadah","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine King Abdulaziz University Hospital and College of Medicine, King Abdulaziz University Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,29]]},"reference":[{"issue":"3","key":"e_1_2_11_2_1","first-page":"169","article-title":"Clinical and electrophysiological evaluation of carpal tunnel syndrome: Approach and pitfalls","volume":"22","author":"Alanazy M. H.","year":"2017","journal-title":"Neuroscience Riyadh Saudi Arabia"},{"issue":"1","key":"e_1_2_11_3_1","first-page":"53","article-title":"The relationship between symptoms, clinical tests and nerve conduction study findings in carpal tunnel syndrome","volume":"49","author":"Ansari N. N.","year":"2009","journal-title":"Electromyography and Clinical Neurophysiology"},{"issue":"2","key":"e_1_2_11_4_1","first-page":"141","article-title":"The usefulness of the Phalen test and the Hoffmann\u2010Tinel sign in the diagnosis of carpal tunnel syndrome","volume":"68","author":"Br\u00fcske J.","year":"2002","journal-title":"Acta Orthopaedica Belgica"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.23.3110"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.58.11.1589"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2004.08.003"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1997.tb00271.x"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1951.02920330018006"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1970.03170210069012"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1957.02980050014005"},{"issue":"3","key":"e_1_2_11_12_1","first-page":"216","article-title":"Correlating nerve conduction studies and clinical outcome measures on carpal tunnel syndrome: Lessons from a randomized controlled trial","volume":"22","author":"Schrijver H. M.","year":"2005","journal-title":"Journal of Clinical Neurophysiology: Official Publication American Electroencephalography Society"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-0712(21)00354-1"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.22208"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.25632"}],"container-title":["Brain and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.2056","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/brb3.2056","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.2056","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T01:52:17Z","timestamp":1693533137000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/brb3.2056"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,29]]},"references-count":14,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1002\/brb3.2056"],"URL":"https:\/\/doi.org\/10.1002\/brb3.2056","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/BRB3.2056\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.2056\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.2056\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.2056\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.2056\/v2\/decision1","asserted-by":"object"}]},"ISSN":["2162-3279","2162-3279"],"issn-type":[{"value":"2162-3279","type":"print"},{"value":"2162-3279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,29]]},"assertion":[{"value":"2020-09-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e02056"}}