{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T18:03:00Z","timestamp":1789495380865,"version":"build-2803163510"},"reference-count":57,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,2,9]],"date-time":"2021-02-09T00:00:00Z","timestamp":1612828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Obsessive\u2010compulsive disorder (OCD) tends to be treatment refractory. Recently, cognitive\u2010coping therapy (CCT) for OCD is reported to be an efficacious psychotherapy. However, the underlying neurophysiological mechanism remains unknown. Here, the effects of CCT on OCD and the resting\u2010state brain function were investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty\u2010nine OCD patients underwent CCT, pharmacotherapy plus CCT (pCCT), or pharmacotherapy. Before and after a 4\u2010week treatment, Yale\u2010Brown obsessive\u2010compulsive scale (Y\u2010BOCS) was evaluated and resting\u2010state functional magnetic resonance imaging (rs\u2010fMRI) was scanned.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with the baseline, significant reduction of Y\u2010BOCS scores was found after four\u2010week treatment (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001) in groups of CCT and pCCT, not in pharmacotherapy. Post\u2010treatment Y\u2010BOCS scores of CCT group and pCCT group were not different, but significantly lower than that of pharmacotherapy group (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001). Compared with pretreatment, two clusters of brain regions with significant change in amplitude of low\u2010frequency fluctuation (ALFF) were obtained in those who treated with CCT and pCCT, but not in those who received pharmacotherapy. The ALFF in cluster 1 (insula, putamen, and postcentral gyrus in left cerebrum) was decreased, while the ALFF in cluster 2 (occipital medial gyrus, occipital inferior gyrus, and lingual gyrus in right hemisphere) was increased after treatment (corrected<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05). The changes of ALFF were correlated with the reduction of Y\u2010BOCS score and were greater in remission than in nonremission. The reduction of the fear of negative events was correlated to the changes of ALFF of clusters and the reduction of Y\u2010BOCS score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The effectiveness of CCT for OCD was related to the alteration of resting\u2010state brain function\u2014the brain plasticity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial Registration<\/jats:title><jats:p>ChiCTR\u2010IPC\u201015005969.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.2059","type":"journal-article","created":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T18:13:43Z","timestamp":1612980823000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Effects of short\u2010term cognitive\u2010coping therapy on resting\u2010state brain function in obsessive\u2010compulsive disorder"],"prefix":"10.1002","volume":"11","author":[{"given":"Jian\u2010Dong","family":"Ma","sequence":"first","affiliation":[{"name":"Xinxiang Medical University Affiliated Second Hospital Xinxiang Henan P. 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