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NAC as a precursor to the antioxidant glutathione modulates glutamatergic, neurotrophic, and inflammatory pathways.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim and discussion<\/jats:title><jats:p>Most NAC studies up to date have been carried out in animal models of various neurological disorders with only a few studies completed in humans. In psychiatry, NAC has been tested in over 20 clinical trials as an adjunctive treatment; however, this topic is beyond the scope of this review. Herein, we discuss NAC molecular, intracellular, and systemic effects, focusing on its potential applications in neurodegenerative diseases including spinocerebellar ataxia, Parkinson's disease, tardive dyskinesia, myoclonus epilepsy of the Unverricht\u2013Lundbor type as well as multiple sclerosis, amyotrophic lateral sclerosis, and Alzheimer's disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Finally, we review the potential applications of NAC to facilitate recovery after traumatic brain injury, cerebral ischemia, and in treatment of cerebrovascular vasospasm after subarachnoid hemorrhage.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.208","type":"journal-article","created":{"date-parts":[[2014,1,13]],"date-time":"2014-01-13T07:24:55Z","timestamp":1389597895000},"page":"108-122","source":"Crossref","is-referenced-by-count":392,"title":["<i>N<\/i>\u2010acetylcysteine (NAC) in neurological disorders: mechanisms of action and therapeutic opportunities"],"prefix":"10.1002","volume":"4","author":[{"given":"Reza","family":"Bavarsad Shahripour","sequence":"first","affiliation":[{"name":"Department of Neurology Comprehensive Stroke Center University of Alabama Birmingham Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark R.","family":"Harrigan","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of Neurosurgery University of Alabama Birmingham Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrei V.","family":"Alexandrov","sequence":"additional","affiliation":[{"name":"Department of Neurology Comprehensive Stroke Center University of Alabama Birmingham Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,1,13]]},"reference":[{"key":"e_1_2_4_2_1","first-page":"467","article-title":"N\u2010acetylcysteine","volume":"5","year":"2000","journal-title":"Altern. 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