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A combined voxel\u2010based morphometry (<jats:styled-content style=\"fixed-case\">VBM<\/jats:styled-content>) and diffusion tensor imaging (<jats:styled-content style=\"fixed-case\">DTI<\/jats:styled-content>) analysis was used to capture gray matter (<jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content>) and white matter changes in<jats:styled-content style=\"fixed-case\">OCD<\/jats:styled-content>patients as compared to pair\u2010matched healthy volunteers. Multiple regression designs explored the relationship between cognition and neuroimaging parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">OCD<\/jats:styled-content>patients had increased mean diffusivity (<jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content>) in<jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content>nodes of the orbitofronto\u2010striatal loop (left dorsal anterior cingulate [<jats:italic>Z<\/jats:italic>\u00a0=\u00a03.67,<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001] left insula [<jats:italic>Z<\/jats:italic>\u00a0=\u00a03.35<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001] left thalamus [<jats:italic>Z<\/jats:italic>\u00a0=\u00a03.59,<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001] left parahippocampal gyrus [<jats:italic>Z<\/jats:italic>\u00a0=\u00a03.77<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001]) and in lateral frontal and posterior associative cortices (right frontal operculum [<jats:italic>Z<\/jats:italic>\u00a0=\u00a03.42<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001], right temporal lobe [<jats:italic>Z<\/jats:italic>\u00a0=\u00a03.79<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001] left parietal lobe [<jats:italic>Z<\/jats:italic>\u00a0=\u00a03.91<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001]). Decreased fractional anisotropy (<jats:styled-content style=\"fixed-case\">FA<\/jats:styled-content>) was detected in intrahemispheric (left superior longitudinal fasciculus [<jats:italic>Z<\/jats:italic>\u00a0=\u00a04.07<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001]) and interhemispheric (body of corpus callosum [<jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>,<jats:italic>Z<\/jats:italic>\u00a0=\u00a04.42<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001]) bundles. Concurrently, the semantic fluency score, a measure of executive control processes, significantly predicted<jats:styled-content style=\"fixed-case\">OCD<\/jats:styled-content>diagnosis (Odds Ratio\u00a0=\u00a01.37; 95% Confidence Intervals\u00a0=\u00a01.09\u20131.73;<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0058), while variation in performance was correlated with increased<jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content>in left temporal (<jats:italic>Z<\/jats:italic>\u00a0=\u00a04.25<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and bilateral parietal regions (left<jats:italic>Z<\/jats:italic>\u00a0=\u00a03.94, right<jats:italic>Z<\/jats:italic>\u00a0=\u00a04.19<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), and decreased<jats:styled-content style=\"fixed-case\">FA<\/jats:styled-content>in the right posterior corona radiata (<jats:italic>Z<\/jats:italic>\u00a0=\u00a04.07<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and the left corticospinal tract (<jats:italic>Z<\/jats:italic>\u00a0=\u00a03.95<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The reported deficit in executive processes and the underlying microstructural alterations may qualify as behavioral and biological markers of<jats:styled-content style=\"fixed-case\">OCD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.212","type":"journal-article","created":{"date-parts":[[2014,1,27]],"date-time":"2014-01-27T07:05:03Z","timestamp":1390806303000},"page":"261-277","source":"Crossref","is-referenced-by-count":46,"title":["Brain microstructural changes and cognitive correlates in patients with pure obsessive compulsive disorder"],"prefix":"10.1002","volume":"4","author":[{"given":"Gianfranco","family":"Spalletta","sequence":"first","affiliation":[{"name":"Department of Clinical and Behavioral Neurology Neuropsychiatry Laboratory IRCCS Santa Lucia Foundation Via Ardeatina 306 00179 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Piras","sequence":"additional","affiliation":[{"name":"Department of Clinical and Behavioral Neurology Neuropsychiatry Laboratory IRCCS Santa Lucia Foundation Via Ardeatina 306 00179 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Fagioli","sequence":"additional","affiliation":[{"name":"Department of Clinical and Behavioral Neurology Neuropsychiatry Laboratory IRCCS Santa Lucia Foundation Via Ardeatina 306 00179 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Caltagirone","sequence":"additional","affiliation":[{"name":"Department of Clinical and Behavioral Neurology Neuropsychiatry Laboratory IRCCS Santa Lucia Foundation Via Ardeatina 306 00179 Rome Italy"},{"name":"Department of Neuroscience Tor Vergata University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Piras","sequence":"additional","affiliation":[{"name":"Department of Clinical and Behavioral Neurology Neuropsychiatry Laboratory IRCCS Santa Lucia Foundation Via Ardeatina 306 00179 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,1,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3956(00)00022-4"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890423349"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.07.007"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.02.018"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-9338(03)00065-8"},{"key":"e_1_2_6_7_1","first-page":"1031","article-title":"Executive functions in obsessive\u2010compulsive disorder: state or trait deficits?","volume":"40","author":"Bannon S.","year":"2006","journal-title":"Aust. 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