{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:04:11Z","timestamp":1790265851700,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The at\u2010risk mental state (ARMS) for psychosis has long played a key role in diathesis\u2010stress models of schizophrenia. More recent studies, however, have called for extending the boundaries of the ARMS construct beyond attenuated psychosis in nonhelp\u2010seeking samples to include not only other vulnerability indicators but also protective factors related to genotype, mental health, personality, and cognition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Accordingly, we assessed in a sample of 100 college students, the ARMS construct with the Brief Prodromal Questionnaire (PQ\u2010B) for psychosis, in conjunction with measures of positive mental health, childhood adversity, psychiatric symptoms, personality traits, social cognition, and genetic variables derived from assays of the serotonin transporter (5\u2010HTTLPR) and the brain\u2010derived neurotrophic factor (BDNF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Higher PQ\u2010B scores correlated positively with vulnerability indicators of childhood adversity and heightened levels of a wide variety of psychiatric symptoms but correlated negatively with protective factors of better overall mental health, social cognition as well as with a distinct NEO profile marked by reduced neuroticism and elevated agreeableness and conscientiousness. Multivariate analyses indicated that a composite ARMS measure comprised of PQ\u2010B scores plus anxiety and depression symptoms revealed significant genotype differences, with lowest risk and highest resilience for allelic carriers of 5\u2010HTTLPR\u2010short and BDNF Met polymorphisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Results provided support for extending the ARMS construct, pointing to important contributions of personality, social cognition, and genes that support neural plasticity in mitigating vulnerability and enhancing resilience and well\u2010being.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.2137","type":"journal-article","created":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T10:41:47Z","timestamp":1619865707000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Psychiatric risk and resilience: Plasticity genes and positive mental health"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4890-8950","authenticated-orcid":false,"given":"Paul G.","family":"Nestor","sequence":"first","affiliation":[{"name":"Department of Psychology University of Massachusetts Boston Boston MA USA"},{"name":"Laboratory of Neuroscience Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Choate Hasler","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Massachusetts Boston Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keira","family":"O'Donovan","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Massachusetts Boston Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah E.","family":"Lapp","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Massachusetts Boston Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara B.","family":"Boodai","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Massachusetts Boston Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Hunter","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Massachusetts Boston Boston MA USA"},{"name":"Laboratory of Neuroendocrinology The Rockefeller University New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-005-0624-4"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1076\/1380-3395(200008)22:4;1-0;FT518"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beth.2015.12.005"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/2167702613505532"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7610.1997.tb01599.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/wps.20092"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1083968"},{"key":"e_1_2_9_9_1","volume-title":"Revised NEO Personality Inventory (NEO\u2010PI\u2010R) and the Five Factor Inventory (NEO\u2010FFI): Professional manual","author":"Costa P. 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