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This is probably due to poor understanding of the mechanisms underlying it.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>We investigated a major class of trigeminal neuropathic pain, dynamic mechanical allodynia (<jats:styled-content style=\"fixed-case\">DMA<\/jats:styled-content>), in a rat model of <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> and in which a bilateral 6\u2010hydroxy dopamine (6\u2010<jats:styled-content style=\"fixed-case\">OHDA<\/jats:styled-content>) injection was administered to produce a lesion of the nigrostriatal dopaminergic pathway.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results and discussion<\/jats:title><jats:p>Lesioned animals presented significant DMA in the orofacial area that occurred from 4 days to 5 weeks post\u2010injury. To investigate a segmental implication in the neuropathic pain induced by dopamine depletion, the expression of the isoform gamma of the protein kinase C (PKCg) and phosphorylated extracellular signal\u2010regulated kinases 1\/2 (<jats:styled-content style=\"fixed-case\">pERK<\/jats:styled-content>1\/2) was explored in the medullary dorsal horn (MDH). There was a high increase in PKCg expression in the III and IIi laminae of the MDH of lesioned\u2010animals compared to shams. <jats:styled-content style=\"fixed-case\">pERK<\/jats:styled-content>1\/2 expression was also significantly high in the ipsilateral MDH of lesioned rats in response to non\u2010noxious tactile stimulus of the orofacial region. Since <jats:styled-content style=\"fixed-case\">pERK<\/jats:styled-content>1\/2 is expressed only in response to nociceptive stimuli in the dorsal spinal horn, the current study demonstrates that non\u2010noxious stimuli evoke allodynic response. Intraperitoneal and intracisternal administrations of bromocriptine, a dopamine 2 receptor (D2R) agonist, significantly decreased <jats:styled-content style=\"fixed-case\">DMA<\/jats:styled-content> compared to control rats injected with saline. These data demonstrate for the first time that nigrostriatal dopaminergic depletion produces trigeminal neuropathic pain that at least involves a segmental mechanism. In addition, bromocriptine was shown to have a remarkable analgesic effect on this neuropathic pain symptom.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.214","type":"journal-article","created":{"date-parts":[[2014,2,21]],"date-time":"2014-02-21T01:48:44Z","timestamp":1392947324000},"page":"368-380","source":"Crossref","is-referenced-by-count":48,"title":["Lesion of the dopaminergic nigrostriatal pathway induces trigeminal dynamic mechanical allodynia"],"prefix":"10.1002","volume":"4","author":[{"given":"Wisam","family":"Dieb","sequence":"first","affiliation":[{"name":"Laboratoire de neuro\u2010psychopharmacology des syst\u00e8mes dopaminergiques sous corticaux Clermont Universit\u00e9 Universit\u00e9 d'Auvergne Clermont\u2010Ferrand EA7280 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Ouachikh","sequence":"additional","affiliation":[{"name":"Laboratoire de neuro\u2010psychopharmacology des syst\u00e8mes dopaminergiques sous corticaux Clermont Universit\u00e9 Universit\u00e9 d'Auvergne Clermont\u2010Ferrand EA7280 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franck","family":"Durif","sequence":"additional","affiliation":[{"name":"Laboratoire de neuro\u2010psychopharmacology des syst\u00e8mes dopaminergiques sous corticaux Clermont Universit\u00e9 Universit\u00e9 d'Auvergne Clermont\u2010Ferrand EA7280 France"},{"name":"Service de Neurologie CHU Clermont\u2010Ferrand Clermont\u2010Ferrand 63000 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aziz","family":"Hafidi","sequence":"additional","affiliation":[{"name":"Laboratoire de neuro\u2010psychopharmacology des syst\u00e8mes dopaminergiques sous corticaux Clermont Universit\u00e9 Universit\u00e9 d'Auvergne Clermont\u2010Ferrand EA7280 France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,2,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(99)00298-2"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2008.09.003"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2007.03.010"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-009-0348-0"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr271"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(74)92219-3"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(88)90027-9"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1999.tb09270.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2004.09.017"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2010.06.001"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(94)00172-B"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2008.03.053"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1741-2358.1998.00073.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2010.08.012"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034513498898"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2005.04.021"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1113\/eph8702357"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a008862"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23959"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2004.07.024"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/16040"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.6175-08.2009"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/117.3.579"},{"key":"e_1_2_7_25_1","first-page":"315","article-title":"The characteristics of autonomic nervous system disorders in burning mouth syndrome and Parkinson disease","volume":"26","author":"Koszewicz M.","year":"2012","journal-title":"J. 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